Basic information of CD40 :

Official Symbol of Gene	CD40
Species	Homo sapiens
Entrez Gene ID	958
Official Full Name	CD40 molecule
Also known as	p50; Bp50; CDW40; TNFRSF5
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000101017 MIM:109535; AllianceGenome:HGNC:11919
Map Location	20q13.12
Drug	Cladribine treatment
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	N/A
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	35734180
Year	2022
Title	Cladribine Treatment for MS Preserves the Differentiative Capacity of Subsequently Generated Monocytes, Whereas Its Administration In Vitro Acutely Influences Monocyte Differentiation but Not Microglial Activation

Results of multiple sclerosis :

Result	In addition, MDMs treated with cladribine showed increased expression of costimulatory molecules CD80 and CD40, as well as expression of anti-inflammatory, pro-trophic genes IL10 and MERTK, depending on the differentiation condition. Cladribine treatment in vitro.
Mechanism/pathway	the costimulatory molecule CD40 as markers of proinflammatory activation