Basic information of AKT1 :

Official Symbol of Gene	AKT1
Species	Homo sapiens
Entrez Gene ID	207
Official Full Name	AKT serine/threonine kinase 1
Also known as	AKT; PKB; RAC; PRKBA; PKB-ALPHA; RAC-ALPHA
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000142208 MIM:164730; AllianceGenome:HGNC:391
Map Location	14q32.33
Drug	LXW7
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	BV2 microglial cell
Disease	chronic neurodegenerative diseases (e.g., Alzheimer′s disease, Parkinson′s disease, multiple sclerosis, amyotrophic lateral sclerosis)

Literature information of multiple sclerosis :

Pubmed ID	31732449
Year	2019
Title	LXW7 attenuates inflammation via suppressing Akt/nuclear factor kappa B and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated BV2 microglial cells

Results of multiple sclerosis :

Result	The anti-inflammatory effects of LXW7 may be associated with the inhibition of microglial activation via Akt/NF-κB and JNK/MAPK signaling pathways by blocking integrin αvβ3 receptor. The present study′s findings suggest that LXW7 has a substantial therapeutic potential for treating inflammatory and neurodegenerative diseases.
Mechanism/pathway	Akt/NF-κB and JNK/MAPK signaling pathways by blocking integrin αvβ3 receptor