Basic information of Nos2 :

Official Symbol of Gene	Nos2
Species	Mus musculus
Entrez Gene ID	18126
Official Full Name	nitric oxide synthase 2, inducible
Also known as	iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000020826 AllianceGenome:MGI:97361
Map Location	11 B5; 11 46.74 cM
Drug	N-[3,4-Dimethoxycinnamoyl]-anthranilic acid (tranilast, TNL)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	brain
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	14505805
Year	2003
Title	Involvement of protein kinase Cd and extracellular signal-regulated kinase-2 in the suppression of microglial inducible nitric oxide synthase expression by N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast)

Results of multiple sclerosis :

Result	In summary, we show that TNL inhibits LPS-induced activation of iNOS by inhibiting the activation of PKCd and ERK-2, thus possibly affecting post-translational modification of iNOS mRNA. Our result may have further implications for the use of TNL as a novel therapeutic agent in neurological disorders associated with activation of microglia and increased NO release, including multiple sclerosis
Mechanism/pathway	PKCd and ERK-2