Basic information of Nos2 :

Official Symbol of Gene	Nos2
Species	Mus musculus
Entrez Gene ID	18126
Official Full Name	nitric oxide synthase 2, inducible
Also known as	iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000020826 AllianceGenome:MGI:97361
Map Location	11 B5; 11 46.74 cM
Drug	kalopanaxsaponin A
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	microglia
Disease	inflammatory effects

Literature information of multiple sclerosis :

Pubmed ID	24244819
Year	2013
Title	Kalopanaxsaponin A Exerts Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated Microglia via Inhibition of JNK and NF-κB/AP-1 Pathways

Results of multiple sclerosis :

Result

we showed that kalopanaxsaponin A, a triterpenoid saponin isolated from Kalopanax pictus, inhibited inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and tumor necrosis factor (TNF)-α expression in lipopolysaccharide (LPS)-stimulated microglia, while kalopanaxsaponin A increased anti-infl ammatory cytokine interleukin (IL)-10 expression. Subsequent mechanistic studies revealed that kalopanaxsaponin A inhibited LPS-induced DNA binding activities of NF-κB and AP-1, and the phosphorylation of JNK without affecting other MAP kinases. Furthermore, kalopanaxsaponin A inhibited the intracellular ROS production with upregulation of anti-infl ammatory hemeoxygenase-1 (HO-1) expression. Based on the previous reports that JNK pathway is largely involved in iNOS and proinfl ammatory cytokine gene expression via modulating NF-κB/AP-1 and ROS, our data collectively suggest that inhibition of JNK pathway plays a key role in anti-infl ammatory effects of kalopanaxsaponin A in LPS-stimulated microglia

Mechanism/pathway

JNK pathway is largely involved in iNOS and proinfl ammatory cytokine gene expression via modulating NF-κB/AP-1 and ROS