Basic information of Cxcl10 :
| Official Symbol of Gene | Cxcl10 |
| Species | Rattus norvegicus |
| Entrez Gene ID | 245920 |
| Official Full Name | C-X-C motif chemokine ligand 10 |
| Also known as | IP-10; Scyb10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000022256AllianceGenome:RGD:620209 |
| Map Location | 14p22 |
| Drug | IFN |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | brainã€spleenã€thymus |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 12115662 |
| Year | 2002 |
| Title | Neutralization of IFN-inducible protein 10/CXCL10 exacerbates experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Result | CXCL10 produced in the LN plays a specific inhibitory role in the development of Th1-mediated diseases such as EAE by holding sensitized and activated Th1s expressing CXCR3 in the draining LN |
| Mechanism/pathway | Induction of gene expression of CXCL9/Mig and CXCL10 and their receptor CXCR3 was confirmed in the draining LN in EAE rats |
