Basic information of Cxcr3 :
| Official Symbol of Gene | Cxcr3 |
| Species | Mus musculus |
| Entrez Gene ID | 12766 |
| Official Full Name | chemokine (C-X-C motif) receptor 3 |
| Also known as | Cd183; Cmkar3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000050232 AllianceGenome:MGI:1277207 |
| Map Location | X D; X 44.58 cM |
| Drug | IFN |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | brainã€spleenã€thymus |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 12115662 |
| Year | 2002 |
| Title | Neutralization of IFN-inducible protein 10/CXCL10 exacerbates experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Result | CXCL10 produced in the LN plays a specific inhibitory role in the development of Th1-mediated diseases such as EAE by holding sensitized and activated Th1s expressing CXCR3 in the draining LN |
| Mechanism/pathway | Induction of gene expression of CXCL9/Mig and CXCL10 and their receptor CXCR3 was confirmed in the draining LN in EAE rats |
