Basic information of CCR5 :

Official Symbol of Gene	CCR5
Species	Homo sapiens
Entrez Gene ID	1234
Official Full Name	C-C motif chemokine receptor 5
Also known as	CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000160791 MIM:601373; AllianceGenome:HGNC:1606
Map Location	3p21.31
Drug	Natalizumab
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	mononuclear cells (PBMCs) and CSF surface cell molecules
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	17911462
Year	2007
Title	Natalizumab in the Treatment of Patients with Multiple Sclerosis First Experience

Results of multiple sclerosis :

Result	Natalizumab treatment alters the percentage of CCR5+ and CD4+ cells in CSF. In view of the excellent temporary clinical results of the therapy, which are yet to be assessed in the course of a longer time period, our results show a possible explanation for the therapeutic success of this drug as well as for the development of progressive multifocal leukoencephalopathy
Mechanism/pathway	CD4+ autoreactive T cells and their differentiation into Th1 phenotype are crucial events in the initial phases