Basic information of IFIH1 :
| Official Symbol of Gene | IFIH1 |
| Species | Homo sapiens |
| Entrez Gene ID | 64135 |
| Official Full Name | interferon induced with helicase C domain 1 |
| Also known as | AGS7; Hlcd; MDA5; IMD95; MDA-5; RLR-2; IDDM19; SGMRT1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115267 MIM:606951; AllianceGenome:HGNC:18873 |
| Map Location | 2q24.2 |
| Drug | IFN-β 1a |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | Peripheral blood |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 32311159 |
| Year | 2020 |
| Title | The effect of IFN-β 1a on expression of MDA5 and RIG-1 in multiple sclerosis patients |
Results of multiple sclerosis :
| Result | Thus, it seems that IFN-β 1a not only decreased pathogenic inflammatory responses but also modulated the expression of RIG-1 to protect the patients from infectious diseases and upregulation of IFN-I in a positive feedback |
| Mechanism/pathway | Melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene 1 (RIG-1) are two critical pathogen recognition receptors (PRRs), which detect intracytoplasmic intracellular dsRNA [10–13]. MDA5 and RIG-1 use the same pathway; they both use interferon promoter stimulator 1 (IPS1) to activate two important transcription factors including interferon regulatory transcription factor 3 (IRF3) and nuclear factor-kappa B (NF-κB) |
