Basic information of Ppara :

Official Symbol of Gene	Ppara
Species	Mus musculus
Entrez Gene ID	19013
Official Full Name	peroxisome proliferator activated receptor alpha
Also known as	Ppar; Nr1c1; PPARalpha; PPAR-alpha; 4933429D07Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000022383 AllianceGenome:MGI:104740
Map Location	15 E2; 15 40.42 cM
Drug	retinoid
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	peripheral blood
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	19737866
Year	2009
Title	The nuclear receptor PPAR selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

Results of multiple sclerosis :

Result	Pharmacologic activation of PPARr prevented removal of the silencing mediator for retinoid and thyroid hormone receptors corepressor from the RORrt promoter in T cells, thus interfering with RORrt transcription
Mechanism/pathway	Control of Th17 differentiation by PPARr involved inhibition of TGF-r/IL-6–induced expression of RORrt in T cells