Basic information of Tnf :

Official Symbol of Gene	Tnf
Species	Mus musculus
Entrez Gene ID	21926
Official Full Name	tumor necrosis factor
Also known as	DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798
Map Location	17 B1; 17 18.59 cM
Drug	treatment with ORY-2001
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	SJL/J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	35890315
Year	2022
Title	Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis

Results of multiple sclerosis :

Result	only the treatment with ORY-2001 significantly reduced the levels of TNF-alpha and MCP-1.
Mechanism/pathway	This cytokine has an important role in initiating and limiting the extent and duration of immune-mediated inflammatory processes, organ damage, cell infiltration to the spinal cord, and demyelination.