Details

Home Details


Basic information of RELA :

Official Symbol of Gene RELA
Species Homo sapiens
Entrez Gene ID 5970
Official Full Name RELA proto-oncogene, NF-kB subunit
Also known as p65; CMCU; NFKB3; AIF3BL3
Gene Type protein coding
dbXrefs Ensembl:ENSG00000173039 MIM:164014; AllianceGenome:HGNC:9955
Map Location 11q13.1
Drug DMF treatment
Interaction Type inhibitor

Sample information of multiple sclerosis:

Descent N/A
Disease MS

Literature information of multiple sclerosis :

Pubmed ID 29106333
Year 2019
Title Monomethyl fumarate treatment impairs maturation of human myeloid dendritic cells and their ability to activate T cells

Results of multiple sclerosis :

Result MMF treatment induced a less mature phenotype of mDCs with reduced expression of major histocompatibility complex class II (MHC-II), co-stimulatory molecules CD86, CD40, CD83, and expression of nuclear factor κB (NF-κB) subunits RELA and RELB.
Mechanism/pathway N/A