Basic information of Trp53 :

Official Symbol of Gene	Trp53
Species	Mus musculus
Entrez Gene ID	22059
Official Full Name	transformation related protein 53
Also known as	bbl; bfy; bhy; p44; p53; Tp53
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000059552 AllianceGenome:MGI:98834
Map Location	11 B3; 11 42.83 cM
Drug	AST treatment
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	25150364
Year	2014
Title	Astragalosides from Radix Astragali benefits experimental autoimmune encephalomyelitis in C57BL /6 mice at multiple levels

Results of multiple sclerosis :

Result	Compared with EAE mice without any treatment, protein expression of GFAP and p53 in AST treated EAE mice were inhibited remarkably(p < 0.05).
Mechanism/pathway	p53 plays a suppressive role in the inflammatory re sponse by regulation the cytokine profile as well as the destiny of infiltrated cells.