| PMID:
29125885
|
| Subject&Disease:
Osteoclastogenesis/Osteoblast differentiation
|
| Sample:
Osteoblast cell
|
| Species:
Mus musculus
|
| ncRNA Category:
miRNA
|
| ncRNA Symbols:
miR-376c
|
| Accession number:
null
|
| chromosome Location:
null
|
| Expression pattern:
Downregulation
|
| High-throughput experiment methods:
Microarray
|
| Low-throughput experiment methods:
RT-PCR,etal
|
| Targets of ncRNA:
Wnt-3 and ARF-GEF-1
|
| Detection methods for targets:
Luciferase reporter assay,RT-PCR, etal
|
| Description the function of ncRNA:
(1) Over-expression of miR-376c inhibited osteoblast differentiation. (2) MiR-376c targets Wnt-3 and ARF-GEF-1 suppresses ARF-6 activation which prevents the release of β-catenin and its transactivation thereby inhibiting osteoblast differentiation.
|
| Year:
2017
|
| Title:
MiR 376c Inhibits Osteoblastogenesis by Targeting Wnt3 and ARF-GEF-1 Facilitated Augmentation of Beta-Catenin Transactivation
|
| External Link:
Ensembl Link
;
HGNC Link
|
