| PMID:
28363268
|
| Subject&Disease:
Osteogenic differentiation
|
| Sample:
Bone marrow extracellular vesicles
|
| Species:
Mus musculus
|
| ncRNA Category:
miRNA
|
| ncRNA Symbols:
miR-183-5p
|
| Accession number:
null
|
| chromosome Location:
null
|
| Expression pattern:
Upregulation
|
| High-throughput experiment methods:
null
|
| Low-throughput experiment methods:
RT-PCR
|
| Targets of ncRNA:
Hmox1
|
| Detection methods for targets:
Luciferase reporter assay,RT-PCR, etal
|
| Description the function of ncRNA:
Aging and oxidative stress can significantly alter the miRNA cargo of EVs in the bone marrow microenvironment, which may in turn play a role in stem cell senescence and osteogenic differentiation by reducing Hmox1 activity.
|
| Year:
2017
|
| Title:
MicroRNA-183-5p Increases with Age in Bone-Derived Extracellular Vesicles, Suppresses Bone Marrow Stromal (Stem) Cell Proliferation, and Induces Stem Cell Senescence.
|
| External Link:
Ensembl Link
;
HGNC Link
|
