| PMID:
28460412
|
| Subject&Disease:
Heterotopic ossification
|
| Sample:
Ligamentum flavum(LF); Cell line (hFOB1.19); Bone marrow mesenchymal stem cells; LF cells
|
| Species:
Homo sapiens
|
| ncRNA Category:
miRNA
|
| ncRNA Symbols:
miR-615-3p
|
| Accession number:
NR_030753
|
| chromosome Location:
Chromosome 12, NC_000012.12 (54033950..54034045)
|
| Expression pattern:
Downregulation
|
| High-throughput experiment methods:
null
|
| Low-throughput experiment methods:
RT-PCR,etal
|
| Targets of ncRNA:
FOXO1 or GDF5
|
| Detection methods for targets:
Luciferase reporter assay, RT-PCR, Western blot
|
| Description the function of ncRNA:
MiR-615-3p negatively regulates the osteogenic differentiation of hLF cells through post-transcriptionally suppressing osteogenic regulators GDF5 and FOXO1.
|
| Year:
2017
|
| Title:
MiR-615-3p inhibits the osteogenic differentiation of human lumbar ligamentum flavum cells via suppression of osteogenic regulators GDF5 and FOXO1.
|
| External Link:
Ensembl Link
;
HGNC Link
|
