| PMID:
28382864
|
| Subject&Disease:
Osteolysis (Particle-Induced)
|
| Sample:
Cell line (preosteoblast MC3T3-E1)
|
| Species:
Mus musculus
|
| ncRNA Category:
miRNA
|
| ncRNA Symbols:
miR-130b
|
| Accession number:
NR_029659.1
|
| chromosome Location:
Chromosome 16, NC_000082.6 (17124061..17124142, complement)
|
| Expression pattern:
Upregulation
|
| High-throughput experiment methods:
null
|
| Low-throughput experiment methods:
RT-PCR,etal
|
| Targets of ncRNA:
FRZB
|
| Detection methods for targets:
Luciferase reporter assay, RT-PCR, Western blot
|
| Description the function of ncRNA:
The upregulated miR-130b in PIO models could act as one key regulator of PIO development, partly due to its negative regulation on FRZB.
|
| Year:
2017
|
| Title:
MicroRNA-130b Promotes Wear Particle-Induced Osteolysis via Downregulating Frizzled-Related Protein (FRZB).
|
| External Link:
Ensembl Link
;
HGNC Link
|
