| PMID:
25052989
|
| Subject&Disease:
Osteoarthritis
|
| Sample:
Fibroblast-like synoviocytes
|
| Species:
Homo sapiens
|
| ncRNA Category:
miRNA
|
| ncRNA Symbols:
miR-146a
|
| Accession number:
null
|
| chromosome Location:
null
|
| Expression pattern:
Upregulation
|
| High-throughput experiment methods:
null
|
| Low-throughput experiment methods:
RT-PCR,etal
|
| Targets of ncRNA:
NF-κB-binding sites
|
| Detection methods for targets:
ChIP, RT-PCR, Western blot,
|
| Description the function of ncRNA:
Denbinobin inhibited IL-1β-induced ICAM-1/VCAM-1 expression and monocyte adhesion to OA-FLS. It was due to denbinobin increased miR-146a level, which in turn inhibited NF-κB signaling.
|
| Year:
2014
|
| Title:
Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes.
|
| External Link:
Ensembl Link
;
HGNC Link
|
