| PMID:
26816250
|
| Subject&Disease:
Osteoarthritis
|
| Sample:
Chondrocytes; Articular cartilage samples
|
| Species:
Homo sapiens
|
| ncRNA Category:
miRNA
|
| ncRNA Symbols:
miR-105
|
| Accession number:
null
|
| chromosome Location:
null
|
| Expression pattern:
Downreguation
|
| High-throughput experiment methods:
Microarray
|
| Low-throughput experiment methods:
RT-PCR,etal
|
| Targets of ncRNA:
Runx2
|
| Detection methods for targets:
Bioinformatics analysis, Luciferase reporter assay, RT-PCR, Western blot
|
| Description the function of ncRNA:
(1) FGF2 inhibits transcription through recruitment of p65 to miR-105 promoter. (2) p65/miR-miR-105 is essential for FGF2-mediated Runx2 and ADAMTS upregulation. (3) miR-105 is downregulated in OA and inversely correlated with Runx2 expression.
|
| Year:
2016
|
| Title:
miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage
|
| External Link:
Ensembl Link
;
HGNC Link
|
