overview
Species -
Disease -
Technology -
Number of spots -
Number of microbiota (genus) -
Number of markers -
Paired single-cell data -
Publication
Slice annotation
  • Spot annotation
  • Spatial co-occurred module
  • Spot deconvolution
  • SVG

H&E Stain

H&E image
The number of cell across transcriptome clusters

Markers of spatial transcriptome clusters

Cluster Gene Pct.1 Pct.2 FC P Value FDR
Expression of marker gene across transcriptome clusters
Marker

Spatial co-expression module in slices

Source Target Corr Module View
Click a spot below

SVG in spatial transcriptome clusters

Gene Moran's I P Value FDR Enriched Spot Cluster View
Abundance of microbiota in slice
  • Microbiota distribution
  • Microbiota expression
Taxonomy

Abundance of microbiota in spots

The UMI across microbiota
Microbiota
Function of high microbiota abundance region

Differential expression of microbiota enriched in boundary region

Gene Mean exp1 Mean exp2 LogFC P value FDR State

Enriched immune pathway in high microbiota abundance region

Pathway GSVA score P value FDR Gene
Functions of microbiota enriched region

* for hypergeometric test between differential expression gene of microbiota in boundary region and signatures for each immune pathway (FDR < 0.05 )


Cell types within high microbiota abundance region
Microbiota (genus)

Spot deconvolution

Cell types associated with microbiota (genus)

Host microbiota co-expression module

Co-expression module of microbiota and gene

To evaluate the potential impact of microbiota on gene expression, Spearman correlation was calculated for the microbiota UMI count and gene expression within the corresponding spots. Gene co-expression module of the selected microbiota was used to perform pathway(GO-BP) enrichment analysis to investigate the potential impact of microbiota on the biological functions.

Microbiota Gene Corr P value FDR View
Host microbiota co-expression module

Enriched GO-BP functions in co-expression modules

Microbiota Pathway P value FDR Gene
Top 5 enriched functions