| HALLMARK_ADIPOGENESIS | ABCA1,ABCB8,ACAA2,ACADL,ACADM,ACADS,ACLY,ACO2,ACOX1,ADCY6,ADIG,ADIPOQ,ADIPOR2,AGPAT3,AIFM1,AK2,ALDH2,ALDOA,ANGPT1,ANGPTL4,APLP2,APOE,ARAF,ARL4A,ATL2,ATP1B3,ATP5PO,BAZ2A,BCKDHA,BCL2L13,BCL6,C3,CAT,CAVIN1,CAVIN2,CCNG2,CD151,CD302,CD36,CDKN2C,CHCHD10,CHUK,CIDEA,CMBL,CMPK1,COL15A1,COL4A1,COQ3,COQ5,COQ9,COX6A1,COX7B,COX8A,CPT2,CRAT,CS,CYC1,CYP4B1,DBT,DDT,DECR1,DGAT1,DHCR7,DHRS7,DHRS7B,DLAT,DLD,DNAJB9,DNAJC15,DRAM2,ECH1,ECHS1,ELMOD3,ELOVL6,ENPP2,EPHX2,ESRRA,ESYT1,ETFB,FABP4,FAH,FZD4,G3BP2,GADD45A,GBE1,GHITM,GPAM,GPAT4,GPD2,GPHN,GPX3,GPX4,GRPEL1,HADH,HIBCH,HSPB8,IDH1,IDH3A,IDH3G,IFNGR1,IMMT,ITGA7,ITIH5,ITSN1,JAGN1,LAMA4,LEP,LIFR,LIPE,LPCAT3,LPL,LTC4S,MAP4K3,MCCC1,MDH2,ME1,MGLL,MGST3,MIGA2,MRAP,MRPL15,MTARC2,MTCH2,MYLK,NABP1,NDUFA5,NDUFAB1,NDUFB7,NDUFS3,NKIRAS1,NMT1,OMD,ORM1,PDCD4,PEMT,PEX14,PFKFB3,PFKL,PGM1,PHLDB1,PHYH,PIM3,PLIN2,POR,PPARG,PPM1B,PPP1R15B,PRDX3,PREB,PTCD3,PTGER3,QDPR,RAB34,REEP5,REEP6,RETN,RETSAT,RIOK3,RMDN3,RNF11,RREB1,RTN3,SAMM50,SCARB1,SCP2,SDHB,SDHC,SLC19A1,SLC1A5,SLC25A1,SLC25A10,SLC27A1,SLC5A6,SLC66A3,SNCG,SOD1,SORBS1,SOWAHC,SPARCL1,SQOR,SSPN,STAT5A,STOM,SUCLG1,SULT1A1,TALDO1,TANK,TKT,TOB1,TST,UBC,UBQLN1,UCK1,UCP2,UQCR10,UQCR11,UQCRC1,UQCRQ,VEGFB,YWHAG |
| HALLMARK_ALLOGRAFT_REJECTION | AARS1,ABCE1,ABI1,ACHE,ACVR2A,AKT1,APBB1,B2M,BCAT1,BCL10,BCL3,BRCA1,C2,CAPG,CARTPT,CCL11,CCL13,CCL19,CCL2,CCL22,CCL4,CCL5,CCL7,CCND2,CCND3,CCR1,CCR2,CCR5,CD1D,CD2,CD247,CD28,CD3D,CD3E,CD3G,CD4,CD40,CD40LG,CD47,CD7,CD74,CD79A,CD80,CD86,CD8A,CD8B,CD96,CDKN2A,CFP,CRTAM,CSF1,CSK,CTSS,CXCL13,CXCL9,CXCR3,DARS1,DEGS1,DYRK3,EGFR,EIF3A,EIF3D,EIF3J,EIF4G3,EIF5A,ELANE,ELF4,EREG,ETS1,F2,F2R,FAS,FASLG,FCGR2B,FGR,FLNA,FYB1,GALNT1,GBP2,GCNT1,GLMN,GPR65,GZMA,GZMB,HCLS1,HDAC9,HIF1A,HLA-A,HLA-DMA,HLA-DMB,HLA-DOA,HLA-DOB,HLA-DQA1,HLA-DRA,HLA-E,HLA-G,ICAM1,ICOSLG,IFNAR2,IFNG,IFNGR1,IFNGR2,IGSF6,IKBKB,IL10,IL11,IL12A,IL12B,IL12RB1,IL13,IL15,IL16,IL18,IL18RAP,IL1B,IL2,IL27RA,IL2RA,IL2RB,IL2RG,IL4,IL4R,IL6,IL7,IL9,INHBA,INHBB,IRF4,IRF7,IRF8,ITGAL,ITGB2,ITK,JAK2,KLRD1,KRT1,LCK,LCP2,LIF,LTB,LY75,LY86,LYN,MAP3K7,MAP4K1,MBL2,MMP9,MRPL3,MTIF2,NCF4,NCK1,NCR1,NLRP3,NME1,NOS2,NPM1,PF4,PRF1,PRKCB,PRKCG,PSMB10,PTPN6,PTPRC,RARS1,RIPK2,RPL39,RPL3L,RPL9,RPS19,RPS3A,RPS9,SIT1,SOCS1,SOCS5,SPI1,SRGN,ST8SIA4,STAB1,STAT1,STAT4,TAP1,TAP2,TAPBP,TGFB1,TGFB2,THY1,TIMP1,TLR1,TLR2,TLR3,TLR6,TNF,TPD52,TRAF2,TRAT1,UBE2D1,UBE2N,WARS1,WAS,ZAP70 |
| HALLMARK_ANDROGEN_RESPONSE | ABCC4,ABHD2,ACSL3,ACTN1,ADAMTS1,ADRM1,AKAP12,AKT1,ALDH1A3,ANKH,APPBP2,ARID5B,AZGP1,B2M,B4GALT1,BMPR1B,CAMKK2,CCND1,CCND3,CDC14B,CDK6,CENPN,DBI,DHCR24,DNAJB9,ELK4,ELL2,ELOVL5,FADS1,FKBP5,GNAI3,GPD1L,GSR,GUCY1A1,H1-0,HERC3,HMGCR,HMGCS1,HOMER2,HPGD,HSD17B14,IDI1,INPP4B,INSIG1,IQGAP2,ITGAV,KLK2,KLK3,KRT19,KRT8,LIFR,LMAN1,MAF,MAK,MAP7,MERTK,MYL12A,NCOA4,NDRG1,NGLY1,NKX3-1,PA2G4,PDLIM5,PGM3,PIAS1,PLPP1,PMEPA1,PTK2B,PTPN21,RAB4A,RPS6KA3,RRP12,SAT1,SCD,SEC24D,SELENOP,SGK1,SLC26A2,SLC38A2,SMS,SORD,SPCS3,SPDEF,SRF,SRP19,STEAP4,STK39,TARP,TMEM50A,TMPRSS2,TNFAIP8,TPD52,TSC22D1,UAP1,UBE2I,UBE2J1,VAPA,XRCC5,XRCC6,ZBTB10,ZMIZ1 |
| HALLMARK_ANGIOGENESIS | APOH,APP,CCND2,COL3A1,COL5A2,CXCL6,FGFR1,FSTL1,ITGAV,JAG1,JAG2,KCNJ8,LPL,LRPAP1,LUM,MSX1,NRP1,OLR1,PDGFA,PF4,PGLYRP1,POSTN,PRG2,PTK2,S100A4,SERPINA5,SLCO2A1,SPP1,STC1,THBD,TIMP1,TNFRSF21,VAV2,VCAN,VEGFA,VTN |
| HALLMARK_APICAL_JUNCTION | ACTA1,ACTB,ACTC1,ACTG1,ACTG2,ACTN1,ACTN2,ACTN3,ACTN4,ADAM15,ADAM23,ADAM9,ADAMTS5,ADRA1B,AKT2,AKT3,ALOX15B,AMH,AMIGO1,AMIGO2,ARHGEF6,ARPC2,ATP1A3,B4GALT1,BAIAP2,BMP1,CADM2,CADM3,CALB2,CAP1,CD209,CD274,CD276,CD34,CD86,CD99,CDH1,CDH11,CDH15,CDH3,CDH4,CDH6,CDH8,CDK8,CDSN,CERCAM,CLDN11,CLDN14,CLDN15,CLDN18,CLDN19,CLDN4,CLDN5,CLDN6,CLDN7,CLDN8,CLDN9,CNN2,CNTN1,COL16A1,COL17A1,COL9A1,CRAT,CRB3,CTNNA1,CTNND1,CX3CL1,DHX16,DLG1,DMP1,DSC1,DSC3,EGFR,EPB41L2,EVL,EXOC4,FBN1,FLNC,FSCN1,FYB1,GAMT,GNAI1,GNAI2,GRB7,GTF2F1,HADH,HRAS,ICAM1,ICAM2,ICAM4,ICAM5,IKBKG,INPPL1,INSIG1,IRS1,ITGA10,ITGA2,ITGA3,ITGA9,ITGB1,ITGB4,JAM3,JUP,KCNH2,KRT31,LAMA3,LAMB3,LAMC2,LAYN,LDLRAP1,LIMA1,MADCAM1,MAP3K20,MAP4K2,MAPK11,MAPK13,MAPK14,MDK,MMP2,MMP9,MPZL1,MPZL2,MSN,MVD,MYH10,MYH9,MYL12B,MYL9,NECTIN1,NECTIN2,NECTIN3,NECTIN4,NEGR1,NEXN,NF1,NF2,NFASC,NHERF4,NLGN2,NLGN3,NRAP,NRTN,NRXN2,PALS1,PARD6G,PARVA,PBX2,PCDH1,PECAM1,PFN1,PIK3CB,PIK3R3,PKD1,PLCG1,PPP2R2C,PTEN,PTK2,PTPRC,RAC2,RASA1,RHOF,RRAS,RSU1,SDC3,SGCE,SHC1,SHROOM2,SIRPA,SKAP2,SLC30A3,SLIT2,SORBS3,SPEG,SRC,STX4,SYK,SYMPK,TAOK2,TGFBI,THBS3,THY1,TIAL1,TJP1,TMEM8B,TNFRSF11B,TRAF1,TRO,TSC1,TSPAN4,TUBG1,VASP,VAV2,VCAM1,VCAN,VCL,VWF,WASL,WNK4,YWHAH,ZYX |
| HALLMARK_APICAL_SURFACE,ADAM10 | ADIPOR2,AFAP1L2,AKAP7,APP,ATP6V0A4,ATP8B1,B4GALT1,BRCA1,CD160,CROCC,CRYBG1,CX3CL1,DCBLD2,EFNA5,EPHB4,FLOT2,GAS1,GATA3,GHRL,GSTM3,HSPB1,IL2RB,IL2RG,LYN,LYPD3,MAL,MDGA1,NCOA6,NTNG1,PCSK9,PKHD1,PLAUR,RHCG,RTN4RL1,SCUBE1,SHROOM2,SLC22A12,SLC2A4,SLC34A3,SRPX,SULF2,THY1,TMEM8B |
| HALLMARK_APOPTOSIS | ADD1,AIFM3,ANKH,ANXA1,APP,ATF3,AVPR1A,BAX,BCAP31,BCL10,BCL2L1,BCL2L10,BCL2L11,BCL2L2,BGN,BID,BIK,BIRC3,BMF,BMP2,BNIP3L,BRCA1,BTG2,BTG3,CASP1,CASP2,CASP3,CASP4,CASP6,CASP7,CASP8,CASP9,CAV1,CCNA1,CCND1,CCND2,CD14,CD2,CD38,CD44,CD69,CDC25B,CDK2,CDKN1A,CDKN1B,CFLAR,CLU,CREBBP,CTH,CTNNB1,CYLD,DAP,DAP3,DCN,DDIT3,DFFA,DIABLO,DNAJA1,DNAJC3,DNM1L,DPYD,EBP,EGR3,EMP1,ENO2,ERBB2,ERBB3,EREG,ETF1,F2,F2R,FAS,FASLG,FDXR,FEZ1,GADD45A,GADD45B,GCH1,GNA15,GPX1,GPX3,GPX4,GSN,GSR,GSTM1,GUCY2D,H1-0,HGF,HMGB2,HMOX1,HSPB1,IER3,IFITM3,IFNB1,IFNGR1,IGF2R,IGFBP6,IL18,IL1A,IL1B,IL6,IRF1,ISG20,JUN,KRT18,LEF1,LGALS3,LMNA,LUM,MADD,MCL1,MGMT,MMP2,NEDD9,NEFH,PAK1,PDCD4,PDGFRB,PEA15,PLAT,PLCB2,PLPPR4,PMAIP1,PPP2R5B,PPP3R1,PPT1,PRF1,PSEN1,PSEN2,PTK2,RARA,RELA,RETSAT,RHOB,RHOT2,RNASEL,ROCK1,SAT1,SATB1,SC5D,SLC20A1,SMAD7,SOD1,SOD2,SPTAN1,SQSTM1,TAP1,TGFB2,TGFBR3,TIMP1,TIMP2,TIMP3,TNF,TNFRSF12A,TNFSF10,TOP2A,TSPO,TXNIP,VDAC2,WEE1,XIAP |
| HALLMARK_BILE_ACID_METABOLISM | ABCA1,ABCA2,ABCA3,ABCA4,ABCA5,ABCA6,ABCA8,ABCA9,ABCD1,ABCD2,ABCD3,ABCG4,ABCG8,ACSL1,ACSL5,AGXT,AKR1D1,ALDH1A1,ALDH8A1,ALDH9A1,AMACR,APOA1,AQP9,AR,ATXN1,BBOX1,BCAR3,BMP6,CAT,CH25H,CROT,CYP27A1,CYP39A1,CYP46A1,CYP7A1,CYP7B1,CYP8B1,DHCR24,DIO1,DIO2,EFHC1,EPHX2,FADS1,FADS2,FDXR,GC,GCLM,GNMT,GNPAT,GSTK1,HACL1,HAO1,HSD17B11,HSD17B4,HSD17B6,HSD3B1,HSD3B7,IDH1,IDH2,IDI1,ISOC1,KLF1,LCK,LIPE,LONP2,MLYCD,NEDD4,NPC1,NR0B2,NR1H4,NR1I2,NR3C2,NUDT12,OPTN,PAOX,PECR,PEX1,PEX11A,PEX11G,PEX12,PEX13,PEX16,PEX19,PEX26,PEX6,PEX7,PFKM,PHYH,PIPOX,PNPLA8,PRDX5,PXMP2,RBP1,RETSAT,RXRA,RXRG,SCP2,SERPINA6,SLC22A18,SLC23A1,SLC23A2,SLC27A2,SLC27A5,SLC29A1,SLC35B2,SLCO1A2,SOAT2,SOD1,SULT1B1,SULT2B1,TFCP2L1,TTR |
| HALLMARK_CHOLESTEROL_HOMEOSTASIS | ABCA2,ACAT2,ACSS2,ACTG1,ADH4,ALCAM,ALDOC,ANTXR2,ANXA13,ANXA5,ATF3,ATF5,ATXN2,AVPR1A,CBS,CD9,CHKA,CLU,CPEB2,CTNNB1,CXCL16,CYP51A1,DHCR7,EBP,ECH1,ERRFI1,ETHE1,FABP5,FADS2,FASN,FBXO6,FDFT1,FDPS,GLDC,GNAI1,GPX8,GSTM2,GUSB,HMGCR,HMGCS1,HSD17B7,IDI1,JAG1,LDLR,LGALS3,LGMN,LPL,LSS,MAL2,MVD,MVK,NFIL3,NIBAN1,NSDHL,PCYT2,PDK3,PLAUR,PLSCR1,PMVK,PNRC1,PPARG,S100A11,SC5D,SCD,SEMA3B,SQLE,SREBF2,STARD4,STX5,TM7SF2,TMEM97,TNFRSF12A,TP53INP1,TRIB3 |
| HALLMARK_COAGULATION | A2M,ACOX2,ADAM9,ANG,ANXA1,APOA1,APOC1,APOC2,APOC3,ARF4,BMP1,C1QA,C1R,C1S,C2,C3,C8A,C8B,C8G,C9,CAPN2,CAPN5,CASP9,CD9,CFB,CFD,CFH,CFI,CLU,COMP,CPB2,CPN1,CPQ,CRIP2,CSRP1,CTSB,CTSE,CTSH,CTSK,CTSO,CTSV,DCT,DPP4,DUSP14,DUSP6,F10,F11,F12,F13B,F2,F2RL2,F3,F8,F9,FBN1,FGA,FGG,FN1,FURIN,FYN,GDA,GNB2,GNG12,GP1BA,GP9,GSN,HMGCS2,HNF4A,HPN,HRG,HTRA1,ISCU,ITGA2,ITGB3,ITIH1,KLF7,KLK8,KLKB1,LAMP2,LEFTY2,LGMN,LRP1,LTA4H,MAFF,MASP2,MBL2,MEP1A,MMP1,MMP10,MMP11,MMP14,MMP15,MMP2,MMP3,MMP7,MMP8,MMP9,MSRB2,MST1,OLR1,P2RY1,PDGFB,PECAM1,PEF1,PF4,PLAT,PLAU,PLEK,PLG,PREP,PROC,PROS1,PROZ,PRSS23,RABIF,RAC1,RAPGEF3,RGN,S100A1,S100A13,SERPINA1,SERPINB2,SERPINC1,SERPINE1,SERPING1,SH2B2,SIRT2,SPARC,TF,TFPI2,THBD,THBS1,TIMP1,TIMP3,TMPRSS6,USP11,VWF,WDR1 |
| HALLMARK_COMPLEMENT | ACTN2,ADAM9,ADRA2B,AKAP10,ANG,ANXA5,APOA4,APOBEC3F,APOBEC3G,APOC1,ATOX1,BRPF3,C1QA,C1QC,C1R,C1S,C2,C3,C4BPB,C9,CA2,CALM1,CALM3,CASP1,CASP10,CASP3,CASP4,CASP5,CASP7,CASP9,CBLB,CCL5,CD36,CD40LG,CD46,CD55,CD59,CDA,CDH13,CDK5R1,CEBPB,CFB,CFH,CLU,COL4A2,CP,CPM,CPQ,CR1,CR2,CSRP1,CTSB,CTSC,CTSD,CTSH,CTSL,CTSO,CTSS,CTSV,CXCL1,DGKG,DGKH,DOCK10,DOCK4,DOCK9,DPP4,DUSP5,DUSP6,DYRK2,EHD1,ERAP2,F10,F2,F3,F5,F7,F8,FCER1G,FCN1,FDX1,FN1,FYN,GATA3,GCA,GMFB,GNAI2,GNAI3,GNB2,GNB4,GNG2,GNGT2,GP1BA,GP9,GPD2,GRB2,GZMA,GZMB,GZMK,HNF4A,HPCAL4,HSPA1A,HSPA5,IL6,IRF1,IRF2,IRF7,ITGAM,ITIH1,JAK2,KCNIP2,KCNIP3,KIF2A,KLK1,KLKB1,KYNU,L3MBTL4,LAMP2,LAP3,LCK,LCP2,LGALS3,LGMN,LIPA,LRP1,LTA4H,LTF,LYN,MAFF,ME1,MMP12,MMP13,MMP14,MMP15,MMP8,MSRB1,MT3,NOTCH4,OLR1,PCLO,PCSK9,PDGFB,PDP1,PFN1,PHEX,PIK3CA,PIK3CG,PIK3R5,PIM1,PLA2G4A,PLA2G7,PLAT,PLAUR,PLEK,PLG,PLSCR1,PPP2CB,PPP4C,PRCP,PRDM4,PREP,PRKCD,PRSS3,PRSS36,PSEN1,PSMB9,RABIF,RAF1,RASGRP1,RBSN,RCE1,RHOG,RNF4,S100A12,S100A13,S100A9,SCG3,SERPINA1,SERPINB2,SERPINC1,SERPINE1,SERPING1,SH2B3,SIRT6,SPOCK2,SRC,STX4,TFPI2,TIMP1,TIMP2,TMPRSS6,TNFAIP3,USP14,USP15,USP16,USP8,VCPIP1,WAS,XPNPEP1,ZEB1,ZFPM2 |
| HALLMARK_DNA_REPAIR | AAAS,ADA,ADCY6,ADRM1,AGO4,AK1,AK3,ALYREF,APRT,ARL6IP1,BCAM,BCAP31,BOLA2,BRF2,CANT1,CCNO,CDA,CETN2,CLP1,CMPK2,COX17,CSTF3,DAD1,DCTN4,DDB1,DDB2,DGCR8,DGUOK,DUT,EDF1,EIF1B,ELL,ELOA,ERCC1,ERCC2,ERCC3,ERCC4,ERCC5,ERCC8,FEN1,GMPR2,GPX4,GSDME,GTF2A2,GTF2B,GTF2F1,GTF2H1,GTF2H3,GTF2H5,GTF3C5,GUK1,HCLS1,HPRT1,IMPDH2,ITPA,LIG1,MPC2,MPG,MRPL40,NCBP2,NELFB,NELFCD,NELFE,NFX1,NME1,NME3,NME4,NPR2,NT5C,NT5C3A,NUDT21,NUDT9,PCNA,PDE4B,PDE6G,PNP,POLA1,POLA2,POLB,POLD1,POLD3,POLD4,POLE4,POLH,POLL,POLR1C,POLR1D,POLR1H,POLR2A,POLR2C,POLR2D,POLR2E,POLR2F,POLR2G,POLR2H,POLR2I,POLR2J,POLR2K,POLR3C,POLR3GL,POM121,PRIM1,RAD51,RAD52,RAE1,RALA,RBX1,REV3L,RFC2,RFC3,RFC4,RFC5,RNMT,RPA2,RPA3,RRM2B,SAC3D1,SDCBP,SEC61A1,SF3A3,SMAD5,SNAPC4,SNAPC5,SRSF6,SSRP1,STX3,SUPT4H1,SUPT5H,SURF1,TAF10,TAF12,TAF13,TAF1C,TAF6,TAF9,TARBP2,TK2,TMED2,TP53,TSG101,TYMS,UMPS,UPF3B,USP11,VPS28,VPS37B,VPS37D,XPC,ZNF707,ZWINT |
| HALLMARK_E2F_TARGETS | AK2,ANP32E,ASF1A,ASF1B,ATAD2,AURKA,AURKB,BARD1,BIRC5,BRCA1,BRCA2,BRMS1L,BUB1B,CBX5,CCNB2,CCNE1,CCP110,CDC20,CDC25A,CDC25B,CDCA3,CDCA8,CDK1,CDK4,CDKN1A,CDKN1B,CDKN2A,CDKN2C,CDKN3,CENPE,CENPM,CHEK1,CHEK2,CIT,CKS1B,CKS2,CNOT9,CSE1L,CTCF,CTPS1,DCK,DCLRE1B,DCTPP1,DDX39A,DEK,DEPDC1,DIAPH3,DLGAP5,DNMT1,DONSON,DSCC1,DUT,E2F8,EED,EIF2S1,ESPL1,EXOSC8,EZH2,GINS1,GINS3,GINS4,GSPT1,H2AX,H2AZ1,HELLS,HMGA1,HMGB2,HMGB3,HMMR,HNRNPD,HUS1,ILF3,ING3,IPO7,JPT1,KIF18B,KIF22,KIF2C,KIF4A,KPNA2,LBR,LIG1,LMNB1,LUC7L3,LYAR,MAD2L1,MCM2,MCM3,MCM4,MCM5,MCM6,MCM7,MELK,MKI67,MLH1,MMS22L,MRE11,MSH2,MTHFD2,MXD3,MYBL2,MYC,NAA38,NAP1L1,NASP,NBN,NCAPD2,NME1,NOLC1,NOP56,NUDT21,NUP107,NUP153,NUP205,ORC2,ORC6,PA2G4,PAICS,PAN2,PCNA,PDS5B,PHF5A,PLK1,PLK4,PMS2,PNN,POLA2,POLD1,POLD2,POLD3,POLE,POLE4,POP7,PPM1D,PPP1R8,PRDX4,PRIM2,PRKDC,PRPS1,PSIP1,PSMC3IP,PTTG1,RACGAP1,RAD1,RAD21,RAD50,RAD51AP1,RAD51C,RAN,RANBP1,RBBP7,RFC1,RFC2,RFC3,RNASEH2A,RPA1,RPA2,RPA3,RRM2,SHMT1,SLBP,SMC1A,SMC3,SMC4,SMC6,SNRPB,SPAG5,SPC24,SPC25,SRSF1,SRSF2,SSRP1,STAG1,STMN1,SUV39H1,SYNCRIP,TACC3,TBRG4,TCF19,TFRC,TIMELESS,TIPIN,TK1,TMPO,TOP2A,TP53,TRA2B,TRIP13,TUBB,TUBG1,UBE2S,UBE2T,UBR7,UNG,USP1,WDR90,WEE1,XPO1,XRCC6,ZW10 |
| HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | ABI3BP,ACTA2,ADAM12,ANPEP,APLP1,AREG,BASP1,BDNF,BGN,BMP1,CADM1,CALD1,CALU,CAP2,CAPG,CCN1,CCN2,CD44,CD59,CDH11,CDH2,CDH6,COL11A1,COL12A1,COL16A1,COL1A1,COL1A2,COL3A1,COL4A1,COL4A2,COL5A1,COL5A2,COL5A3,COL6A2,COL6A3,COL7A1,COL8A2,COLGALT1,COMP,COPA,CRLF1,CTHRC1,CXCL1,CXCL12,CXCL6,CXCL8,DAB2,DCN,DKK1,DPYSL3,DST,ECM1,ECM2,EDIL3,EFEMP2,ELN,EMP3,ENO2,FAP,FAS,FBLN1,FBLN2,FBLN5,FBN1,FBN2,FERMT2,FGF2,FLNA,FMOD,FN1,FOXC2,FSTL1,FSTL3,FUCA1,FZD8,GADD45A,GADD45B,GAS1,GEM,GJA1,GLIPR1,GPC1,GPX7,GREM1,HTRA1,ID2,IGFBP2,IGFBP3,IGFBP4,IL15,IL32,IL6,INHBA,ITGA2,ITGA5,ITGAV,ITGB1,ITGB3,ITGB5,JUN,LAMA1,LAMA2,LAMA3,LAMC1,LAMC2,LGALS1,LOX,LOXL1,LOXL2,LRP1,LRRC15,LUM,MAGEE1,MATN2,MATN3,MCM7,MEST,MFAP5,MGP,MMP1,MMP14,MMP2,MMP3,MSX1,MXRA5,MYL9,MYLK,NID2,NNMT,NOTCH2,NT5E,NTM,OXTR,P3H1,PCOLCE,PCOLCE2,PDGFRB,PDLIM4,PFN2,PLAUR,PLOD1,PLOD2,PLOD3,PMEPA1,PMP22,POSTN,PPIB,PRRX1,PRSS2,PTHLH,PTX3,PVR,QSOX1,RGS4,RHOB,SAT1,SCG2,SDC1,SDC4,SERPINE1,SERPINE2,SERPINH1,SFRP1,SFRP4,SGCB,SGCD,SGCG,SLC6A8,SLIT2,SLIT3,SNAI2,SNTB1,SPARC,SPOCK1,SPP1,TAGLN,TFPI2,TGFB1,TGFBI,TGFBR3,TGM2,THBS1,THBS2,THY1,TIMP1,TIMP3,TNC,TNFAIP3,TNFRSF11B,TNFRSF12A,TPM1,TPM2,TPM4,VCAM1,VCAN,VEGFA,VEGFC,VIM,WIPF1,WNT5A |
| HALLMARK_ESTROGEN_RESPONSE_EARLY | ABAT,ABCA3,ABHD2,ABLIM1,ADCY1,ADCY9,ADD3,AFF1,AKAP1,ALDH3B1,AMFR,ANXA9,AQP3,AR,AREG,ARL3,ASB13,B4GALT1,BAG1,BCL11B,BCL2,BHLHE40,BLVRB,CA12,CALB2,CALCR,CANT1,CBFA2T3,CCN5,CCND1,CD44,CELSR1,CELSR2,CHPT1,CISH,CLDN7,CLIC3,CXCL12,CYP26B1,DEPTOR,DHCR7,DHRS2,DHRS3,DLC1,DYNLT3,EEIG1,EGR3,ELF1,ELF3,ELOVL2,ELOVL5,ENDOD1,ESRP2,FARP1,FASN,FCMR,FDFT1,FHL2,FKBP4,FKBP5,FLNB,FOS,FOXC1,FRK,GAB2,GFRA1,GJA1,GLA,GREB1,HES1,HR,HSPB8,IGF1R,IGFBP4,IL17RB,IL6ST,INHBB,INPP5F,ISG20L2,ITPK1,JAK2,KAZN,KCNK15,KCNK5,KDM4B,KLF10,KLF4,KLK10,KRT13,KRT15,KRT18,KRT19,KRT8,LAD1,LRIG1,MAPT,MAST4,MED13L,MED24,MICB,MINDY1,MLPH,MPPED2,MREG,MSMB,MUC1,MYB,MYBBP1A,MYBL1,MYC,MYOF,NADSYN1,NAV2,NBL1,NCOR2,NHERF1,NPY1R,NRIP1,NXT1,OLFM1,OLFML3,OPN3,OVOL2,P2RY2,PAPSS2,PDLIM3,PDZK1,PEX11A,PGR,PLAAT3,PMAIP1,PODXL,PPIF,PRSS23,PTGES,RAB17,RAB31,RAPGEFL1,RARA,RASGRP1,RBBP8,REEP1,RET,RETREG1,RHOBTB3,RHOD,RPS6KA2,RRP12,SCARB1,SCNN1A,SEC14L2,SEMA3B,SFN,SH3BP5,SIAH2,SLC16A1,SLC19A2,SLC1A1,SLC1A4,SLC22A5,SLC24A3,SLC26A2,SLC27A2,SLC2A1,SLC37A1,SLC39A6,SLC7A2,SLC7A5,SNX24,SOX3,STC2,SULT2B1,SVIL,SYBU,SYNGR1,SYT12,TBC1D30,TFAP2C,TFF1,TFF3,TGIF2,TGM2,THSD4,TIAM1,TIPARP,TJP3,TMEM164,TMPRSS3,TOB1,TPBG,TPD52L1,TSKU,TTC39A,TUBB2B,UGCG,UNC119,WFS1,WWC1,XBP1,ZNF185 |
| HALLMARK_ESTROGEN_RESPONSE_LATE | ABCA3,ABHD2,ACOX2,ADD3,AFF1,AGR2,ALDH3A2,ALDH3B1,AMFR,ANXA9,AREG,ARL3,ASCL1,ASS1,ATP2B4,BAG1,BATF,BCL2,BLVRB,BTG3,CA12,CA2,CACNA2D2,CALCR,CAV1,CCN5,CCNA1,CCND1,CD44,CD9,CDC20,CDC6,CDH1,CELSR2,CHPT1,CHST8,CISH,CKB,CLIC3,COX6C,CPE,CXCL12,CXCL14,CYP26B1,CYP4F11,DCXR,DHCR7,DHRS2,DLG5,DNAJC1,DNAJC12,DUSP2,DYNLT3,EEIG1,EGR3,ELOVL5,EMP2,ETFB,FABP5,FARP1,FDFT1,FGFR3,FKBP4,FKBP5,FLNB,FOS,FOXC1,FRK,GAL,GALE,GFUS,GINS2,GJB3,GLA,GPER1,HMGCS2,HOMER2,HPRT1,HR,HSPA4L,HSPB8,ID2,IDH2,IGFBP4,IGSF1,IL17RB,IL6ST,IMPA2,ISG20,ITPK1,JAK1,JAK2,KCNK5,KIF20A,KLF4,KLK10,KLK11,KRT13,KRT19,LAMC2,LARGE1,LLGL2,LSR,LTF,MAPK13,MAPT,MDK,MEST,METTL3,MICB,MOCS2,MYB,MYOF,NAB2,NBL1,NCOR2,NHERF1,NMU,NPY1R,NRIP1,NXT1,OLFM1,OPN3,OVOL2,PAPSS2,PCP4,PDCD4,PDLIM3,PDZK1,PERP,PGR,PKP3,PLAAT3,PLAC1,PLK4,PLXNB1,PPIF,PRKAR2B,PRLR,PRSS23,PTGER3,PTGES,PTPN6,RAB31,RABEP1,RAPGEFL1,RBBP8,RET,RNASEH2A,RPS6KA2,S100A9,SCARB1,SCNN1A,SCUBE2,SEMA3B,SERPINA1,SERPINA3,SERPINA5,SFN,SGK1,SIAH2,SLC16A1,SLC1A4,SLC22A5,SLC24A3,SLC26A2,SLC27A2,SLC29A1,SLC2A8,SLC7A5,SNX10,SORD,SOX3,ST14,ST6GALNAC2,STIL,SULT2B1,TFAP2C,TFF1,TFF3,TFPI2,TH,TIAM1,TJP3,TMPRSS3,TNNC1,TOB1,TOP2A,TPBG,TPD52L1,TPSAB1,TRIM29,TSPAN13,TST,UGDH,UNC13B,WFS1,XBP1,XRCC3,ZFP36 |
| HALLMARK_FATTY_ACID_METABOLISM | AADAT,ACAA1,ACAA2,ACADL,ACADM,ACADS,ACADVL,ACAT2,ACO2,ACOT2,ACOT8,ACOX1,ACSL1,ACSL4,ACSL5,ACSM3,ACSS1,ADH1C,ADH7,ADIPOR2,ADSL,ALAD,ALDH1A1,ALDH3A1,ALDH3A2,ALDH9A1,ALDOA,AOC3,APEX1,AQP7,AUH,BCKDHB,BLVRA,BMPR1B,BPHL,CA2,CA4,CA6,CBR1,CBR3,CD1D,CD36,CEL,CIDEA,CPOX,CPT1A,CPT2,CRAT,CRYZ,CYP1A1,CYP4A11,CYP4A22,D2HGDH,DECR1,DHCR24,DLD,DLST,ECH1,ECHS1,ECI1,ECI2,EHHADH,ELOVL5,ENO2,ENO3,EPHX1,ERP29,ETFDH,FABP1,FABP2,FASN,FH,FMO1,G0S2,GABARAPL1,GAD2,GAPDHS,GCDH,GLUL,GPD1,GPD2,GRHPR,GSTZ1,H2AZ1,HADH,HADHB,HAO2,HCCS,HIBCH,HMGCL,HMGCS1,HMGCS2,HPGD,HSD17B10,HSD17B11,HSD17B4,HSD17B7,HSDL2,HSP90AA1,HSPH1,IDH1,IDH3B,IDH3G,IDI1,IL4I1,INMT,KMT5A,LDHA,LGALS1,LTC4S,MAOA,MCEE,MDH1,MDH2,ME1,METAP1,MGLL,MIF,MIX23,MLYCD,NBN,NCAPH2,NSDHL,NTHL1,ODC1,OSTC,PCBD1,PDHA1,PDHB,PPARA,PRDX6,PSME1,PTPRG,PTS,RAP1GDS1,RDH11,RDH16,REEP6,RETSAT,S100A10,SDHA,SDHC,SDHD,SERINC1,SLC22A5,SMS,SUCLA2,SUCLG1,SUCLG2,TDO2,TP53INP2,UBE2L6,UGDH,UROD,UROS,VNN1,XIST,YWHAH |
| HALLMARK_G2M_CHECKPOINT | ABL1,AMD1,ARID4A,ATF5,ATRX,AURKA,AURKB,BARD1,BCL3,BIRC5,BRCA2,BUB1,BUB3,CASP8AP2,CBX1,CCNA2,CCNB2,CCND1,CCNF,CCNT1,CDC20,CDC25A,CDC25B,CDC27,CDC45,CDC6,CDC7,CDK1,CDK4,CDKN1B,CDKN2C,CDKN3,CENPA,CENPE,CENPF,CHAF1A,CHEK1,CHMP1A,CKS1B,CKS2,CTCF,CUL1,CUL3,CUL4A,CUL5,DBF4,DDX39A,DKC1,DMD,DR1,DTYMK,E2F1,E2F2,E2F3,E2F4,EFNA5,EGF,ESPL1,EWSR1,EXO1,EZH2,FANCC,FBXO5,FOXN3,G3BP1,GINS2,GSPT1,H2AX,H2AZ1,H2AZ2,H2BC12,HIF1A,HIRA,HMGA1,HMGB3,HMGN2,HMMR,HNRNPD,HNRNPU,HOXC10,HSPA8,HUS1,ILF3,INCENP,JPT1,KATNA1,KIF11,KIF15,KIF20B,KIF22,KIF23,KIF2C,KIF4A,KIF5B,KMT5A,KNL1,KPNA2,KPNB1,LBR,LIG3,LMNB1,MAD2L1,MAP3K20,MAPK14,MARCKS,MCM2,MCM3,MCM5,MCM6,MEIS1,MEIS2,MKI67,MNAT1,MT2A,MTF2,MYBL2,MYC,NASP,NCL,NDC80,NEK2,NOLC1,NOTCH2,NSD2,NUMA1,NUP50,NUP98,NUSAP1,ODC1,ODF2,ORC5,ORC6,PAFAH1B1,PBK,PDS5B,PLK1,PLK4,PML,POLA2,POLE,POLQ,PRC1,PRIM2,PRMT5,PRPF4B,PTTG1,PTTG3P,PURA,RACGAP1,RAD21,RAD23B,RAD54L,RASAL2,RBL1,RBM14,RPA2,RPS6KA5,SAP30,SFPQ,SLC12A2,SLC38A1,SLC7A1,SLC7A5,SMAD3,SMARCC1,SMC1A,SMC2,SMC4,SNRPD1,SQLE,SRSF1,SRSF10,SRSF2,SS18,STAG1,STIL,STMN1,SUV39H1,SYNCRIP,TACC3,TENT4A,TFDP1,TGFB1,TLE3,TMPO,TNPO2,TOP1,TOP2A,TPX2,TRA2B,TRAIP,TROAP,TTK,UBE2C,UBE2S,UCK2,UPF1,WRN,XPO1,YTHDC1 |
| HALLMARK_GLYCOLYSIS | ABCB6,ADORA2B,AGL,AGRN,AK3,AK4,AKR1A1,ALDH7A1,ALDH9A1,ALDOA,ALDOB,ALG1,ANG,ANGPTL4,ANKZF1,ARPP19,ARTN,AURKA,B3GALT6,B3GAT1,B3GAT3,B3GNT3,B4GALT1,B4GALT2,B4GALT4,B4GALT7,BIK,BPNT1,CACNA1H,CAPN5,CASP6,CD44,CDK1,CENPA,CHPF,CHPF2,CHST1,CHST12,CHST2,CHST4,CHST6,CITED2,CLDN3,CLDN9,CLN6,COG2,COL5A1,COPB2,CTH,CXCR4,CYB5A,DCN,DDIT4,DEPDC1,DLD,DPYSL4,DSC2,ECD,EFNA3,EGFR,EGLN3,ELF3,ENO1,ENO2,ERO1A,EXT1,EXT2,FAM162A,FBP2,FKBP4,FUT8,G6PD,GAL3ST1,GALE,GALK1,GALK2,GAPDHS,GCLC,GFPT1,GFUS,GLCE,GLRX,GMPPA,GMPPB,GNE,GNPDA1,GOT1,GOT2,GPC1,GPC3,GPC4,GPR87,GUSB,GYS1,GYS2,HAX1,HDLBP,HK2,HMMR,HOMER1,HS2ST1,HS6ST2,HSPA5,IDH1,IDUA,IER3,IGFBP3,IL13RA1,IRS2,ISG20,KDELR3,KIF20A,KIF2A,LCT,LDHA,LDHC,LHPP,LHX9,MDH1,MDH2,ME1,ME2,MED24,MERTK,MET,MIF,MIOX,MPI,MXI1,NANP,NASP,NDST3,NDUFV3,NOL3,NSDHL,NT5E,P4HA1,P4HA2,PAM,PAXIP1,PC,PDK3,PFKFB1,PFKP,PGAM1,PGAM2,PGK1,PGLS,PGM2,PHKA2,PKM,PKP2,PLOD1,PLOD2,PMM2,POLR3K,PPFIA4,PPIA,PPP2CB,PRPS1,PSMC4,PYGB,PYGL,QSOX1,RARS1,RBCK1,RPE,RRAGD,SAP30,SDC1,SDC2,SDC3,SDHC,SLC16A3,SLC25A10,SLC25A13,SLC35A3,SLC37A4,SOD1,SOX9,SPAG4,SRD5A3,STC1,STC2,STMN1,TALDO1,TFF3,TGFA,TGFBI,TKTL1,TPBG,TPI1,TPST1,TXN,UGP2,VCAN,VEGFA,VLDLR,XYLT2,ZNF292 |
| HALLMARK_HEDGEHOG_SIGNALING | ACHE,ADGRG1,AMOT,CDK5R1,CDK6,CELSR1,CNTFR,CRMP1,DPYSL2,ETS2,GLI1,HEY1,HEY2,L1CAM,LDB1,MYH9,NF1,NKX6-1,NRCAM,NRP1,NRP2,OPHN1,PLG,PML,PTCH1,RASA1,RTN1,SCG2,SHH,SLIT1,THY1,TLE1,TLE3,UNC5C,VEGFA,VLDLR |
| HALLMARK_HEME_METABOLISM | ABCB6,ABCG2,ACKR1,ACP5,ACSL6,ADD1,ADD2,ADIPOR1,AGPAT4,AHSP,ALAD,ALAS2,ALDH1L1,ALDH6A1,ANK1,AQP3,ARHGEF12,ARL2BP,ASNS,ATG4A,ATP6V0A1,BACH1,BCAM,BLVRA,BLVRB,BMP2K,BNIP3L,BPGM,BSG,BTG2,BTRC,C3,CA1,CA2,CAST,CAT,CCDC28A,CCND3,CDC27,CDR2,CIR1,CLCN3,CLIC2,CPOX,CROCCP2,CTNS,CTSB,CTSE,DAAM1,DCAF10,DCAF11,DCUN1D1,DMTN,E2F2,EIF2AK1,ELL2,ENDOD1,EPB41,EPB42,EPOR,ERMAP,EZH1,FBXO34,FBXO7,FBXO9,FECH,FN3K,FOXJ2,FOXO3,FTCD,GAPVD1,GATA1,GCLC,GCLM,GDE1,GLRX5,GMPS,GYPA,GYPB,GYPC,GYPE,H1-0,H4C3,HAGH,HBB,HBBP1,HBD,HBQ1,HBZ,HDGF,HEBP1,HMBS,HTATIP2,HTRA2,ICAM4,IGSF3,ISCA1,KAT2B,KDM7A,KEL,KHNYN,KLF1,KLF3,LAMP2,LMO2,LPIN2,LRP10,MAP2K3,MARCHF2,MARCHF8,MARK3,MBOAT2,MFHAS1,MGST3,MINPP1,MKRN1,MOCOS,MOSPD1,MPP1,MXI1,MYL4,NARF,NCOA4,NEK7,NFE2,NFE2L1,NNT,NR3C1,NUDT4,OPTN,OSBP2,P4HA2,PC,PDZK1IP1,PGLS,PICALM,PIGQ,PPOX,PPP2R5B,PRDX2,PSMD9,RAD23A,RANBP10,RAP1GAP,RBM38,RBM5,RCL1,RHAG,RHCE,RHD,RIOK3,RNF123,RNF19A,SDCBP,SEC14L1,SELENBP1,SIDT2,SLC10A3,SLC11A2,SLC22A4,SLC25A37,SLC25A38,SLC2A1,SLC30A1,SLC30A10,SLC4A1,SLC66A2,SLC6A8,SLC6A9,SLC7A11,SMOX,SNCA,SPTA1,SPTB,SYNJ1,TAL1,TCEA1,TENT5C,TFDP2,TFRC,TMCC2,TMEM9B,TNRC6B,TNS1,TOP1,TRAK2,TRIM10,TRIM58,TSPAN5,TSPO2,TYR,UBAC1,UCP2,UROD,UROS,USP15,VEZF1,XK,XPO7,YPEL5 |
| HALLMARK_HYPOXIA | ACKR3,ADM,ADORA2B,AK4,AKAP12,ALDOA,ALDOB,ALDOC,AMPD3,ANGPTL4,ANKZF1,ANXA2,ATF3,ATP7A,B3GALT6,B4GALNT2,BCAN,BCL2,BGN,BHLHE40,BNIP3L,BRS3,BTG1,CA12,CASP6,CAV1,CAVIN1,CAVIN3,CCN1,CCN2,CCN5,CCNG2,CDKN1A,CDKN1B,CDKN1C,CHST2,CHST3,CITED2,COL5A1,CP,CSRP2,CXCR4,DCN,DDIT3,DDIT4,DPYSL4,DTNA,DUSP1,EDN2,EFNA1,EFNA3,EGFR,ENO1,ENO2,ENO3,ERO1A,ERRFI1,ETS1,EXT1,F3,FAM162A,FBP1,FOS,FOSL2,FOXO3,GAA,GALK1,GAPDH,GAPDHS,GBE1,GCK,GCNT2,GLRX,GPC1,GPC3,GPC4,GPI,GRHPR,GYS1,HAS1,HDLBP,HEXA,HK1,HK2,HMOX1,HOXB9,HS3ST1,HSPA5,IDS,IER3,IGFBP1,IGFBP3,IL6,ILVBL,INHA,IRS2,ISG20,JMJD6,JUN,KDELR3,KDM3A,KIF5A,KLF6,KLF7,KLHL24,LALBA,LARGE1,LDHA,LDHC,LOX,LXN,MAFF,MAP3K1,MIF,MT1E,MT2A,MXI1,MYH9,NAGK,NCAN,NDRG1,NDST1,NDST2,NEDD4L,NFIL3,NOCT,NR3C1,P4HA1,P4HA2,PAM,PCK1,PDGFB,PDK1,PDK3,PFKFB3,PFKL,PFKP,PGAM2,PGF,PGK1,PGM1,PGM2,PHKG1,PIM1,PKLR,PKP1,PLAC8,PLAUR,PLIN2,PNRC1,PPARGC1A,PPFIA4,PPP1R15A,PPP1R3C,PRDX5,PRKCA,PYGM,RBPJ,RORA,RRAGD,S100A4,SAP30,SCARB1,SDC2,SDC3,SDC4,SELENBP1,SERPINE1,SIAH2,SLC25A1,SLC2A1,SLC2A3,SLC2A5,SLC37A4,SLC6A6,SRPX,STBD1,STC1,STC2,SULT2B1,TES,TGFB3,TGFBI,TGM2,TIPARP,TKTL1,TMEM45A,TNFAIP3,TPBG,TPD52,TPI1,TPST2,UGP2,VEGFA,VHL,VLDLR,WSB1,XPNPEP1,ZFP36,ZNF292 |
| HALLMARK_IL2_STAT5_SIGNALING | ABCB1,ADAM19,AGER,AHCY,AHNAK,AHR,ALCAM,AMACR,ANXA4,APLP1,ARL4A,BATF,BATF3,BCL2,BCL2L1,BHLHE40,BMP2,BMPR2,CA2,CAPG,CAPN3,CASP3,CCND2,CCND3,CCNE1,CCR4,CD44,CD48,CD79B,CD81,CD83,CD86,CDC42SE2,CDC6,CDCP1,CDKN1C,CISH,CKAP4,COCH,COL6A1,CSF1,CSF2,CST7,CTLA4,CTSZ,CXCL10,CYFIP1,DCPS,DENND5A,DHRS3,DRC1,ECM1,EEF1AKMT1,EMP1,ENO3,ENPP1,EOMES,ETFBKMT,ETV4,F2RL2,FAH,FGL2,FLT3LG,FURIN,GABARAPL1,GADD45B,GALM,GATA1,GBP4,GLIPR2,GPR65,GPR83,GPX4,GSTO1,GUCY1B1,HIPK2,HK2,HOPX,HUWE1,HYCC2,ICOS,IFITM3,IFNGR1,IGF1R,IGF2R,IKZF2,IKZF4,IL10,IL10RA,IL13,IL18R1,IL1R2,IL1RL1,IL2RA,IL2RB,IL3RA,IL4R,IRF4,IRF6,IRF8,ITGA6,ITGAE,ITGAV,ITIH5,KLF6,LCLAT1,LIF,LRIG1,LRRC8C,LTB,MAFF,MAP3K8,MAP6,MAPKAPK2,MUC1,MXD1,MYC,MYO1C,MYO1E,NCOA3,NCS1,NDRG1,NFIL3,NFKBIZ,NOP2,NRP1,NT5E,ODC1,P2RX4,P4HA1,PDCD2L,PENK,PHLDA1,PHTF2,PIM1,PLAGL1,PLEC,PLIN2,PLPP1,PLSCR1,PNP,POU2F1,PRAF2,PRKCH,PRNP,PTCH1,PTGER2,PTH1R,PTRH2,PUS1,RABGAP1L,RGS16,RHOB,RHOH,RNH1,RORA,RRAGD,S100A1,SCN9A,SELL,SELP,SERPINB6,SERPINC1,SH3BGRL2,SHE,SLC1A5,SLC29A2,SLC2A3,SLC39A8,SMPDL3A,SNX14,SNX9,SOCS1,SOCS2,SPP1,SPRED2,SPRY4,ST3GAL4,SWAP70,SYNGR2,SYT11,TGM2,TIAM1,TLR7,TNFRSF18,TNFRSF1B,TNFRSF21,TNFRSF4,TNFRSF8,TNFRSF9,TNFSF10,TNFSF11,TRAF1,TTC39B,TWSG1,UCK2,UMPS,WLS,XBP1 |
| HALLMARK_IL6_JAK_STAT3_SIGNALING | A2M,ACVR1B,ACVRL1,BAK1,CBL,CCL7,CCR1,CD14,CD36,CD38,CD44,CD9,CNTFR,CRLF2,CSF1,CSF2,CSF2RA,CSF2RB,CSF3R,CXCL1,CXCL10,CXCL11,CXCL13,CXCL3,CXCL9,DNTT,EBI3,FAS,GRB2,HAX1,HMOX1,IFNAR1,IFNGR1,IFNGR2,IL10RB,IL12RB1,IL13RA1,IL15RA,IL17RA,IL17RB,IL18R1,IL1B,IL1R1,IL1R2,IL2RA,IL2RG,IL3RA,IL4R,IL6,IL6ST,IL7,IL9R,INHBE,IRF1,IRF9,ITGA4,ITGB3,JUN,LEPR,LTB,LTBR,MAP3K8,MYD88,OSMR,PDGFC,PF4,PIK3R5,PIM1,PLA2G2A,PTPN1,PTPN11,PTPN2,REG1A,SOCS1,SOCS3,STAM2,STAT1,STAT2,STAT3,TGFB1,TLR2,TNF,TNFRSF12A,TNFRSF1A,TNFRSF1B,TNFRSF21,TYK2 |
| HALLMARK_INFLAMMATORY_RESPONSE | ABCA1,ABI1,ACVR1B,ACVR2A,ADGRE1,ADM,ADORA2B,ADRM1,AHR,APLNR,AQP9,ATP2A2,ATP2B1,ATP2C1,AXL,BDKRB1,BEST1,BST2,BTG2,C3AR1,C5AR1,CALCRL,CCL17,CCL2,CCL20,CCL22,CCL24,CCL5,CCL7,CCR7,CCRL2,CD14,CD40,CD48,CD55,CD69,CD70,CD82,CDKN1A,CHST2,CLEC5A,CMKLR1,CSF1,CSF3,CSF3R,CX3CL1,CXCL10,CXCL11,CXCL6,CXCL8,CXCL9,CXCR6,CYBB,DCBLD2,EBI3,EDN1,EIF2AK2,EMP3,EREG,F3,FFAR2,FPR1,FZD5,GABBR1,GCH1,GNA15,GNAI3,GP1BA,GPC3,GPR132,GPR183,HAS2,HBEGF,HIF1A,HPN,HRH1,ICAM1,ICAM4,ICOSLG,IFITM1,IFNAR1,IFNGR2,IL10,IL10RA,IL12B,IL15,IL15RA,IL18,IL18R1,IL18RAP,IL1A,IL1B,IL1R1,IL2RB,IL4R,IL6,IL7R,INHBA,IRAK2,IRF1,IRF7,ITGA5,ITGB3,ITGB8,KCNA3,KCNJ2,KCNMB2,KIF1B,KLF6,LAMP3,LCK,LCP2,LDLR,LIF,LPAR1,LTA,LY6E,LYN,MARCO,MEFV,MEP1A,MET,MMP14,MSR1,MXD1,MYC,NAMPT,NDP,NFKB1,NFKBIA,NLRP3,NMI,NMUR1,NOD2,NPFFR2,OLR1,OPRK1,OSM,OSMR,P2RX4,P2RX7,P2RY2,PCDH7,PDE4B,PDPN,PIK3R5,PLAUR,PROK2,PSEN1,PTAFR,PTGER2,PTGER4,PTGIR,PTPRE,PVR,RAF1,RASGRP1,RELA,RGS1,RGS16,RHOG,RIPK2,RNF144B,ROS1,RTP4,SCARF1,SCN1B,SELE,SELENOS,SELL,SEMA4D,SERPINE1,SGMS2,SLAMF1,SLC11A2,SLC1A2,SLC28A2,SLC31A1,SLC31A2,SLC4A4,SLC7A1,SLC7A2,SPHK1,SRI,STAB1,TACR1,TACR3,TAPBP,TIMP1,TLR1,TLR2,TLR3,TNFAIP6,TNFRSF1B,TNFRSF9,TNFSF10,TNFSF15,TNFSF9,TPBG,VIP |
| HALLMARK_INTERFERON_ALPHA_RESPONSE | ADAR,B2M,BATF2,BST2,C1S,CASP1,CASP8,CCRL2,CD47,CD74,CMPK2,CMTR1,CNP,CSF1,CXCL10,CXCL11,DDX60,DHX58,EIF2AK2,ELF1,EPSTI1,GBP2,GBP4,GMPR,HELZ2,HERC6,HLA-C,IFI27,IFI30,IFI35,IFI44,IFI44L,IFIH1,IFIT2,IFIT3,IFITM1,IFITM2,IFITM3,IL15,IL4R,IL7,IRF1,IRF2,IRF7,IRF9,ISG15,ISG20,LAMP3,LAP3,LGALS3BP,LPAR6,LY6E,MOV10,MVB12A,MX1,NCOA7,NMI,NUB1,OAS1,OASL,OGFR,PARP12,PARP14,PARP9,PLSCR1,PNPT1,PROCR,PSMA3,PSMB8,PSMB9,PSME1,PSME2,RIPK2,RNF31,RSAD2,RTP4,SAMD9,SAMD9L,SELL,SLC25A28,SP110,STAT2,TAP1,TDRD7,TENT5A,TMEM140,TRAFD1,TRIM14,TRIM21,TRIM25,TRIM26,TRIM5,TXNIP,UBA7,UBE2L6,USP18,WARS1 |
| HALLMARK_INTERFERON_GAMMA_RESPONSE | ADAR,APOL6,ARID5B,ARL4A,AUTS2,B2M,BANK1,BATF2,BPGM,BST2,BTG1,C1R,C1S,CASP1,CASP3,CASP4,CASP7,CASP8,CCL2,CCL5,CCL7,CD274,CD38,CD40,CD69,CD74,CD86,CDKN1A,CFB,CFH,CIITA,CMKLR1,CMPK2,CMTR1,CSF2RB,CXCL10,CXCL11,CXCL9,DDX60,DHX58,EIF2AK2,EIF4E3,EPSTI1,FAS,FCGR1A,FGL2,FPR1,GBP4,GBP6,GCH1,GPR18,GZMA,HELZ2,HERC6,HIF1A,HLA-A,HLA-B,HLA-DMA,HLA-DQA1,HLA-DRB1,HLA-G,ICAM1,IDO1,IFI27,IFI30,IFI35,IFI44,IFI44L,IFIH1,IFIT1,IFIT2,IFIT3,IFITM2,IFITM3,IFNAR2,IL10RA,IL15,IL15RA,IL18BP,IL2RB,IL4R,IL6,IL7,IRF1,IRF2,IRF4,IRF5,IRF7,IRF8,IRF9,ISG15,ISG20,ISOC1,ITGB7,JAK2,KLRK1,LAP3,LATS2,LCP2,LGALS3BP,LY6E,LYSMD2,MARCHF1,METTL7B,MT2A,MTHFD2,MVP,MX1,MX2,MYD88,NAMPT,NCOA3,NFKB1,NFKBIA,NLRC5,NMI,NOD1,NUP93,OAS2,OAS3,OASL,OGFR,P2RY14,PARP12,PARP14,PDE4B,PELI1,PFKP,PIM1,PLA2G4A,PLSCR1,PML,PNP,PNPT1,PSMA2,PSMA3,PSMB10,PSMB2,PSMB8,PSMB9,PSME1,PSME2,PTGS2,PTPN1,PTPN2,PTPN6,RAPGEF6,RBCK1,RIGI,RIPK1,RIPK2,RNF213,RNF31,RSAD2,RTP4,SAMD9L,SAMHD1,SECTM1,SELP,SERPING1,SLAMF7,SLC25A28,SOCS1,SOCS3,SOD2,SP110,SPPL2A,SRI,SSPN,ST3GAL5,ST8SIA4,STAT1,STAT2,STAT3,STAT4,TAP1,TAPBP,TDRD7,TNFAIP2,TNFAIP3,TNFAIP6,TNFSF10,TOR1B,TRAFD1,TRIM14,TRIM21,TRIM25,TRIM26,TXNIP,UBE2L6,UPP1,USP18,VAMP5,VAMP8,VCAM1,WARS1,XAF1,XCL1,ZBP1,ZNFX1 |
| HALLMARK_KRAS_SIGNALING_DN | ABCB11,ABCG4,ACTC1,ADRA2C,AKR1B10,ALOX12B,AMBN,ARHGDIG,ARPP21,ASB7,ATP4A,ATP6V1B1,BARD1,BMPR1B,BRDT,BTG2,C5,CACNA1F,CACNG1,CALCB,CALML5,CAMK1D,CAPN9,CCDC106,CCNA1,CCR8,CD207,CD40LG,CD80,CDH16,CDKAL1,CELSR2,CHRNG,CHST2,CKM,CLDN16,CLDN8,CLPS,CLSTN3,CNTFR,COL2A1,COPZ2,COQ8A,CPA2,CPB1,CPEB3,CYP11B2,CYP39A1,DCC,DLK2,DTNB,EDAR,EDN1,EDN2,EFHD1,EGF,ENTPD7,EPHA5,FGF16,FGF22,FGFR3,FGGY,FSHB,GAMT,GDNF,GP1BA,GP2,GPR19,GPR3,GPRC5C,GRID2,GTF3C5,HNF1A,HSD11B2,HTR1B,HTR1D,IDUA,IFI44L,IFNG,IGFBP2,IL12B,IL5,INSL5,IRS4,ITGB1BP2,ITIH3,KCND1,KCNE2,KCNMB1,KCNN1,KCNQ2,KLHDC8A,KLK7,KLK8,KMT2D,KRT1,KRT13,KRT15,KRT4,KRT5,LFNG,LGALS7,LYPD3,MACROH2A2,MAGIX,MAST3,MEFV,MFSD6,MSH5,MTHFR,MX1,MYH7,MYO15A,MYOT,NGB,NOS1,NPHS1,NPY4R,NR4A2,NR6A1,NRIP2,NTF3,NUDT11,OXT,P2RX6,P2RY4,PAX3,PAX4,PCDHB1,PDCD1,PDE6B,PDK2,PKP1,PLAG1,PNMT,PRKN,PRODH,PROP1,PTGFR,PTPRJ,RGS11,RIBC2,RSAD2,RYR1,RYR2,SCGB1A1,SCN10A,SELENOP,SERPINA10,SERPINB2,SGK1,SHOX2,SIDT1,SKIL,SLC12A3,SLC16A7,SLC25A23,SLC29A3,SLC30A3,SLC38A3,SLC5A5,SLC6A14,SLC6A3,SMPX,SNCB,SNN,SOX10,SPHK2,SPRR3,SPTBN2,SSTR4,STAG3,SYNPO,TAS2R4,TCF7L1,TCL1A,TENM2,TENT5C,TEX15,TFAP2B,TFCP2L1,TFF2,TG,TGFB2,TGM1,THNSL2,THRB,TLX1,TNNI3,TSHB,UGT2B17,UPK3B,VPREB1,VPS50,WNT16,YBX2,YPEL1,ZBTB16,ZC2HC1C,ZNF112 |
| HALLMARK_KRAS_SIGNALING_UP | ABCB1,ACE,ADAM17,ADAM8,ADAMDEC1,ADGRA2,ADGRL4,AKAP12,AKT2,ALDH1A2,ALDH1A3,AMMECR1,ANGPTL4,ANKH,ANO1,ANXA10,APOD,ARG1,ATG10,AVL9,BIRC3,BMP2,BPGM,BTBD3,BTC,C3AR1,CA2,CAB39L,CBL,CBR4,CBX8,CCL20,CCND2,CCSER2,CD37,CDADC1,CFB,CFH,CFHR2,CIDEA,CLEC4A,CMKLR1,CPE,CROT,CSF2,CSF2RA,CTSS,CXCL10,CXCR4,DCBLD2,DNMBP,DOCK2,DUSP6,EMP1,ENG,EPB41L3,EPHB2,EREG,ERO1A,ETS1,ETV1,ETV4,ETV5,EVI5,F13A1,F2RL1,FBXO4,FCER1G,FGF9,FLT4,FUCA1,G0S2,GABRA3,GADD45G,GALNT3,GFPT2,GLRX,GNG11,GPNMB,GPRC5B,GUCY1A1,GYPC,H2BC3,HBEGF,HDAC9,HKDC1,HOXD11,HSD11B1,ID2,IGF2,IGFBP3,IKZF1,IL10RA,IL1B,IL1RL2,IL2RG,IL33,IL7R,INHBA,IRF8,ITGA2,ITGB2,ITGBL1,JUP,KCNN4,KIF5C,KLF4,LAPTM5,LAT2,LCP1,LIF,LY96,MAFB,MALL,MAP3K1,MAP4K1,MAP7,MMD,MMP10,MMP11,MMP9,MPZL2,MTMR10,MYCN,NAP1L2,NGF,NIN,NR0B2,NR1H4,NRP1,PCP4,PCSK1N,PDCD1LG2,PECAM1,PEG3,PIGR,PLAT,PLAU,PLAUR,PLEK2,PLVAP,PPBP,PPP1R15A,PRDM1,PRELID3B,PRKG2,PRRX1,PSMB8,PTBP2,PTCD2,PTGS2,PTPRR,RABGAP1L,RBM4,RBP4,RELN,RETN,RGS16,SATB1,SCG3,SCG5,SCN1B,SDCCAG8,SEMA3B,SERPINA3,SLPI,SNAP25,SNAP91,SOX9,SPARCL1,SPON1,SPP1,SPRY2,ST6GAL1,STRN,TFPI,TLR8,TMEM100,TMEM158,TMEM176A,TMEM176B,TNFAIP3,TNFRSF1B,TNNT2,TOR1AIP2,TPH1,TRAF1,TRIB1,TRIB2,TSPAN1,TSPAN13,TSPAN7,USH1C,USP12,VWA5A,WDR33,WNT7A,YRDC,ZNF277,ZNF639 |
| HALLMARK_MITOTIC_SPINDLE | ABI1,ABL1,ABR,ACTN4,AKAP13,ALMS1,ALS2,ANLN,APC,ARAP3,ARF6,ARFGEF1,ARFIP2,ARHGAP10,ARHGAP27,ARHGAP29,ARHGAP4,ARHGAP5,ARHGDIA,ARHGEF11,ARHGEF12,ARHGEF2,ARHGEF3,ARHGEF7,ARL8A,ATG4B,AURKA,BCAR1,BCL2L11,BCR,BIN1,BIRC5,BRCA2,BUB1,CAPZB,CCDC88A,CCNB2,CD2AP,CDC27,CDC42,CDC42BPA,CDC42EP1,CDC42EP2,CDC42EP4,CDK1,CDK5RAP2,CENPE,CENPF,CENPJ,CEP131,CEP192,CEP250,CEP57,CEP72,CKAP5,CLASP1,CLIP1,CLIP2,CNTRL,CNTROB,CSNK1D,CTTN,CYTH2,DLG1,DLGAP5,DOCK2,DOCK4,DST,DYNC1H1,DYNLL2,ECT2,EPB41,EPB41L2,ESPL1,EZR,FARP1,FBXO5,FGD4,FGD6,FLNA,FLNB,FSCN1,GEMIN4,GSN,HDAC6,HOOK3,INCENP,ITSN1,KATNA1,KATNB1,KIF11,KIF15,KIF1B,KIF20B,KIF22,KIF23,KIF2C,KIF3B,KIF3C,KIF4A,KIF5B,KIFAP3,KLC1,KNTC1,KPTN,LATS1,LLGL1,LMNB1,LRPPRC,MAP1S,MAP3K11,MAPRE1,MARCKS,MARK4,MID1,MID1IP1,MYH10,MYH9,MYO1E,MYO9B,NCK1,NCK2,NDC80,NEDD9,NEK2,NET1,NF1,NIN,NOTCH2,NUMA1,NUSAP1,OPHN1,PAFAH1B1,PALLD,PCGF5,PCM1,PCNT,PDLIM5,PIF1,PKD2,PLEKHG2,PLK1,PPP4R2,PRC1,PREX1,PXN,RAB3GAP1,RABGAP1,RACGAP1,RALBP1,RANBP9,RAPGEF5,RAPGEF6,RASA1,RASA2,RASAL2,RFC1,RHOF,RHOT2,RICTOR,ROCK1,SAC3D1,SASS6,SEPTIN9,SHROOM1,SHROOM2,SMC1A,SMC3,SMC4,SORBS2,SOS1,SPTAN1,SPTBN1,SSH2,STAU1,STK38L,SUN2,SYNPO,TAOK2,TBCD,TIAM1,TLK1,TOP2A,TPX2,TRIO,TSC1,TTK,TUBA4A,TUBD1,TUBGCP2,TUBGCP3,TUBGCP5,TUBGCP6,UXT,VCL,WASF1,WASF2,WASL,YWHAE |
| HALLMARK_MTORC1_SIGNALING | ABCF2,ACACA,ACLY,ACSL3,ACTR2,ACTR3,ADD3,ADIPOR2,AK4,ALDOA,ARPC5L,ASNS,ATP2A2,ATP5MC1,ATP6V1D,AURKA,BCAT1,BHLHE40,BTG2,BUB1,CACYBP,CALR,CANX,CCNF,CCNG1,CCT6A,CD9,CDC25A,CDKN1A,CFP,COPS5,CORO1A,CTH,CTSC,CXCR4,CYB5B,CYP51A1,DAPP1,DDIT3,DDIT4,DDX39A,DHCR24,DHCR7,DHFR,EBP,EDEM1,EEF1E1,EGLN3,EIF2S2,ELOVL5,ELOVL6,ENO1,EPRS1,ERO1A,ETF1,FADS1,FADS2,FDXR,FGL2,FKBP2,G6PD,GAPDH,GBE1,GCLC,GGA2,GLA,GLRX,GMPS,GOT1,GPI,GSK3B,GSR,GTF2H1,HK2,HMBS,HMGCR,HMGCS1,HPRT1,HSP90B1,HSPA4,HSPA5,HSPA9,HSPD1,HSPE1,IDH1,IDI1,IFI30,IFRD1,IGFBP5,IMMT,INSIG1,ITGB2,LDHA,LDLR,LGMN,LTA4H,M6PR,MAP2K3,MCM2,MCM4,ME1,MLLT11,MTHFD2,MTHFD2L,NAMPT,NFIL3,NFKBIB,NFYC,NHERF1,NIBAN1,NMT1,NUFIP1,NUP205,NUPR1,P4HA1,PDAP1,PDK1,PFKL,PGK1,PGM1,PHGDH,PIK3R3,PITPNB,PLK1,PLOD2,PNO1,PNP,POLR3G,PPA1,PPIA,PPP1R15A,PRDX1,PSAT1,PSMA3,PSMA4,PSMB5,PSMC2,PSMC4,PSMC6,PSMD12,PSMD13,PSMD14,PSME3,PSMG1,PSPH,QDPR,RAB1A,RDH11,RIT1,RPA1,RPN1,RRM2,RRP9,SC5D,SCD,SDF2L1,SEC11A,SERP1,SERPINH1,SHMT2,SKAP2,SLA,SLC1A4,SLC1A5,SLC2A1,SLC2A3,SLC37A4,SLC6A6,SLC7A11,SLC7A5,SORD,SQLE,SQSTM1,SRD5A1,SSR1,STARD4,STC1,STIP1,SYTL2,TBK1,TCEA1,TES,TFRC,TM7SF2,TMEM97,TOMM40,TPI1,TRIB3,TUBA4A,TUBG1,TXNRD1,UBE2D3,UCHL5,UFM1,UNG,USO1,VLDLR,WARS1,XBP1,YKT6 |
| HALLMARK_MYC_TARGETS_V1 | ABCE1,ACP1,AIMP2,AP3S1,APEX1,BUB3,C1QBP,CAD,CANX,CBX3,CCNA2,CCT2,CCT3,CCT4,CCT5,CCT7,CDC20,CDC45,CDK2,CDK4,CLNS1A,CNBP,COPS5,COX5A,CSTF2,CTPS1,CUL1,CYC1,DDX18,DDX21,DEK,DHX15,DUT,EEF1B2,EIF1AX,EIF2S1,EIF2S2,EIF3B,EIF3D,EIF3J,EIF4A1,EIF4E,EIF4G2,EIF4H,EPRS1,ERH,ETF1,EXOSC7,FAM120A,FBL,G3BP1,GLO1,GNL3,GOT2,GSPT1,H2AZ1,HDAC2,HDDC2,HDGF,HNRNPA1,HNRNPA2B1,HNRNPA3,HNRNPC,HNRNPD,HNRNPR,HNRNPU,HPRT1,HSP90AB1,HSPD1,HSPE1,IARS1,IFRD1,ILF2,IMPDH2,KARS1,KPNA2,KPNB1,LDHA,LSM2,LSM7,MAD2L1,MCM2,MCM4,MCM5,MCM6,MCM7,MRPL23,MRPL9,MRPS18B,MYC,NAP1L1,NCBP1,NCBP2,NDUFAB1,NHP2,NME1,NOLC1,NOP16,NOP56,NPM1,ODC1,ORC2,PA2G4,PABPC1,PABPC4,PCBP1,PCNA,PGK1,PHB1,PHB2,POLD2,POLE3,PPIA,PPM1G,PRDX3,PRDX4,PRPF31,PRPS2,PSMA1,PSMA2,PSMA4,PSMA6,PSMA7,PSMB2,PSMB3,PSMC4,PSMC6,PSMD1,PSMD14,PSMD3,PSMD7,PSMD8,PTGES3,PWP1,RACK1,RAD23B,RAN,RANBP1,RFC4,RNPS1,RPL14,RPL18,RPL22,RPL34,RPL6,RPLP0,RPS10,RPS2,RPS3,RPS5,RPS6,RRM1,RRP9,RSL1D1,RUVBL2,SERBP1,SET,SF3A1,SF3B3,SLC25A3,SMARCC1,SNRPA,SNRPA1,SNRPB2,SNRPD1,SNRPD2,SNRPD3,SNRPG,SRM,SRPK1,SRSF1,SRSF2,SRSF3,SRSF7,SSB,SSBP1,STARD7,SYNCRIP,TARDBP,TCP1,TFDP1,TOMM70,TRA2B,TRIM28,TUFM,TXNL4A,TYMS,U2AF1,UBA2,UBE2E1,UBE2L3,USP1,VBP1,VDAC1,VDAC3,XPO1,XPOT,XRCC6,YWHAE,YWHAQ |
| HALLMARK_MYC_TARGETS_V2 | AIMP2,BYSL,CBX3,CDK4,DCTPP1,DDX18,DUSP2,EXOSC5,FARSA,GNL3,GRWD1,HK2,HSPD1,HSPE1,IMP4,IPO4,LAS1L,MAP3K6,MCM4,MCM5,MPHOSPH10,MRTO4,MYBBP1A,MYC,NDUFAF4,NIP7,NOC4L,NOLC1,NOP16,NOP2,NOP56,NPM1,PA2G4,PES1,PHB1,PLK1,PLK4,PPAN,PPRC1,PRMT3,PUS1,RABEPK,RCL1,RRP12,RRP9,SLC19A1,SLC29A2,SORD,SRM,SUPV3L1,TBRG4,TCOF1,TFB2M,TMEM97,UNG,UTP20,WDR43,WDR74 |
| HALLMARK_MYOGENESIS | ABLIM1,ACHE,ACSL1,ACTA1,ACTC1,ACTN2,ACTN3,ADAM12,ADCY9,AEBP1,AGL,AGRN,AK1,AKT2,ANKRD2,APLNR,APOD,APP,ATP2A1,ATP6AP1,BAG1,BDKRB2,BHLHE40,BIN1,CACNA1H,CACNG1,CAMK2B,CASQ1,CASQ2,CAV3,CD36,CDH13,CDKN1A,CFD,CHRNA1,CHRNB1,CHRNG,CKB,CKM,CKMT2,CLU,CNN3,COL15A1,COL1A1,COL3A1,COL4A2,COL6A2,COL6A3,COX6A2,COX7A1,CRAT,CRYAB,CSRP3,CTF1,DAPK2,DENND2B,DES,DMD,DMPK,DTNA,EFS,EIF4A2,ENO3,EPHB3,ERBB3,FABP3,FDPS,FGF2,FHL1,FKBP1B,FLII,FOXO4,FST,FXYD1,GAA,GABARAPL2,GADD45B,GJA5,GNAO1,GPX3,GSN,HBEGF,HDAC5,HRC,HSPB2,HSPB8,IFRD1,IGF1,IGFBP3,IGFBP7,ITGA7,ITGB1,ITGB4,ITGB5,KCNH1,KCNH2,KIFC3,KLF5,LAMA2,LARGE1,LDB3,LPIN1,LSP1,MAPK12,MAPRE3,MB,MEF2A,MEF2C,MEF2D,MRAS,MYBPC3,MYBPH,MYF6,MYH1,MYH11,MYH2,MYH3,MYH4,MYH7,MYH8,MYH9,MYL1,MYL11,MYL2,MYL3,MYL4,MYL6B,MYL7,MYLK,MYO1C,MYOG,MYOM1,MYOM2,MYOZ1,NAV2,NCAM1,NOS1,NOTCH1,NQO1,OCEL1,PC,PDE4DIP,PDLIM7,PFKM,PGAM2,PICK1,PKIA,PLXNB2,PPFIA4,PPP1R3C,PRNP,PSEN2,PTGIS,PTP4A3,PVALB,PYGM,RB1,REEP1,RIT1,RYR1,SCD,SCHIP1,SGCA,SGCD,SGCG,SH2B1,SH3BGR,SIRT2,SLC6A8,SLN,SMTN,SOD3,SORBS1,SORBS3,SPARC,SPDEF,SPEG,SPHK1,SPTAN1,SSPN,STC2,SVIL,SYNGR2,TAGLN,TCAP,TEAD4,TGFB1,TNNC1,TNNC2,TNNI1,TNNI2,TNNT1,TNNT2,TNNT3,TPD52L1,TPM2,TPM3,TSC2,VIPR1,WWTR1 |
| HALLMARK_NOTCH_SIGNALING | APH1A,ARRB1,CCND1,CUL1,DLL1,DTX1,DTX2,DTX4,FBXW11,FZD1,FZD5,FZD7,HES1,HEYL,JAG1,KAT2A,LFNG,MAML2,NOTCH1,NOTCH2,NOTCH3,PPARD,PRKCA,PSEN2,PSENEN,RBX1,SAP30,SKP1,ST3GAL6,TCF7L2,WNT2,WNT5A |
| HALLMARK_OXIDATIVE_PHOSPHORYLATION | ABCB7,ACAA1,ACAA2,ACADM,ACADSB,ACADVL,ACAT1,ACO2,AFG3L2,AIFM1,ALAS1,ALDH6A1,ATP1B1,ATP5F1A,ATP5F1B,ATP5F1C,ATP5F1D,ATP5F1E,ATP5MC1,ATP5MC2,ATP5MC3,ATP5ME,ATP5MF,ATP5MG,ATP5PB,ATP5PD,ATP5PF,ATP5PO,ATP6AP1,ATP6V0B,ATP6V0C,ATP6V0E1,ATP6V1C1,ATP6V1D,ATP6V1E1,ATP6V1F,ATP6V1G1,ATP6V1H,BAX,BCKDHA,BDH2,CASP7,COX10,COX11,COX15,COX17,COX4I1,COX5A,COX5B,COX6A1,COX6B1,COX6C,COX7A2,COX7A2L,COX7B,COX7C,COX8A,CPT1A,CS,CYB5A,CYB5R3,CYC1,CYCS,DECR1,DLAT,DLD,DLST,ECH1,ECHS1,ECI1,ETFA,ETFB,ETFDH,FDX1,FH,FXN,GLUD1,GOT2,GPI,GPX4,GRPEL1,HADHA,HADHB,HCCS,HSD17B10,HSPA9,HTRA2,IDH1,IDH2,IDH3A,IDH3B,IDH3G,IMMT,ISCA1,ISCU,LDHA,LDHB,LRPPRC,MAOB,MDH1,MDH2,MFN2,MGST3,MPC1,MRPL11,MRPL15,MRPL34,MRPL35,MRPS11,MRPS12,MRPS15,MRPS22,MRPS30,MTRF1,MTRR,MTX2,NDUFA1,NDUFA2,NDUFA3,NDUFA4,NDUFA5,NDUFA6,NDUFA7,NDUFA8,NDUFA9,NDUFAB1,NDUFB1,NDUFB2,NDUFB3,NDUFB4,NDUFB5,NDUFB6,NDUFB7,NDUFB8,NDUFC1,NDUFC2,NDUFS1,NDUFS2,NDUFS3,NDUFS4,NDUFS6,NDUFS7,NDUFS8,NDUFV1,NDUFV2,NNT,NQO2,OAT,OGDH,OPA1,OXA1L,PDHA1,PDHB,PDHX,PDK4,PDP1,PHB2,PHYH,PMPCA,POLR2F,POR,PRDX3,RETSAT,RHOT1,RHOT2,SDHA,SDHB,SDHC,SDHD,SLC25A11,SLC25A12,SLC25A20,SLC25A3,SLC25A4,SLC25A5,SLC25A6,SUCLA2,SUCLG1,SUPV3L1,SURF1,TCIRG1,TIMM10,TIMM13,TIMM17A,TIMM50,TIMM8B,TIMM9,TOMM22,TOMM70,UQCR10,UQCR11,UQCRB,UQCRC1,UQCRC2,UQCRFS1,UQCRH,UQCRQ,VDAC1,VDAC2,VDAC3 |
| HALLMARK_P53_PATHWAY | ABAT,ABCC5,ABHD4,ACVR1B,ADA,AEN,AK1,ALOX15B,ANKRA2,APAF1,APP,ATF3,BAIAP2,BAK1,BAX,BLCAP,BMP2,BTG1,BTG2,CASP1,CCND2,CCND3,CCNG1,CCNK,CCP110,CD81,CD82,CDH13,CDK5R1,CDKN1A,CDKN2A,CDKN2AIP,CDKN2B,CEBPA,CGRRF1,CLCA2,COQ8A,CSRNP2,CTSD,CTSF,CYFIP2,DCXR,DDB2,DDIT3,DDIT4,DEF6,DGKA,DNTTIP2,DRAM1,EI24,ELP1,EPHA2,EPHX1,EPS8L2,ERCC5,F2R,FAM162A,FAS,FBXW7,FDXR,FGF13,FOS,FOXO3,FUCA1,GADD45A,GLS2,GM2A,GPX2,H1-2,H2AC25,H2AJ,HBEGF,HDAC3,HEXIM1,HINT1,HMOX1,HRAS,HSPA4L,IER3,IER5,IFI30,IL1A,INHBB,IP6K2,IRAG2,IRAK1,ISCU,ITGB4,JAG2,JUN,KIF13B,KLF4,KLK8,KRT17,LDHB,LIF,MAPKAPK3,MDM2,MKNK2,MXD1,MXD4,NDRG1,NHLH2,NINJ1,NOL8,NOTCH1,NUDT15,NUPR1,OSGIN1,PCNA,PDGFA,PERP,PHLDA3,PIDD1,PITPNC1,PLK2,PLK3,PLXNB2,PMM1,POLH,POM121,PPM1D,PPP1R15A,PRKAB1,PRMT2,PROCR,PTPN14,PTPRE,PVT1,RAB40C,RACK1,RAD51C,RAD9A,RALGDS,RAP2B,RB1,RCHY1,RETSAT,RGS16,RHBDF2,RNF19B,RPL18,RPL36,RPS12,RPS27L,RRAD,RRP8,RXRA,S100A10,S100A4,SAT1,SDC1,SEC61A1,SERPINB5,SERTAD3,SESN1,SFN,SLC19A2,SLC35D1,SLC3A2,SLC7A11,SOCS1,SP1,SPHK1,ST14,STEAP3,STOM,TAP1,TAX1BP3,TCHH,TCN2,TGFA,TGFB1,TM4SF1,TM7SF3,TNFSF9,TNNI1,TOB1,TP53,TP63,TPD52L1,TPRKB,TRAF4,TRAFD1,TRIAP1,TRIB3,TSC22D1,TSPYL2,TXNIP,UPP1,VAMP8,VDR,VWA5A,WRAP73,WWP1,XPC,ZBTB16,ZFP36L1,ZMAT3,ZNF365 |
| HALLMARK_PANCREAS_BETA_CELLS | ABCC8,AKT3,CHGA,DCX,DPP4,ELP4,FOXA2,FOXO1,G6PC2,GCG,GCK,HNF1A,IAPP,INS,INSM1,ISL1,LMO2,MAFB,NEUROD1,NEUROG3,NKX2-2,NKX6-1,PAK3,PAX4,PAX6,PCSK1,PCSK2,PDX1,PKLR,SCGN,SEC11A,SLC2A2,SPCS1,SRP14,SRP9,SRPRB,SST,STXBP1,SYT13,VDR |
| HALLMARK_PEROXISOME | ABCB1,ABCB4,ABCB9,ABCC5,ABCC8,ABCD1,ABCD2,ABCD3,ACAA1,ACOT8,ACOX1,ACSL1,ACSL4,ACSL5,ALB,ALDH1A1,ALDH9A1,ATXN1,BCL10,CACNA1B,CADM1,CAT,CDK7,CEL,CLN6,CLN8,CNBP,CRABP1,CRABP2,CRAT,CTBP1,CTPS1,DHCR24,DHRS3,DIO1,DLG4,ECH1,ECI2,EHHADH,ELOVL5,EPHX2,ERCC1,ERCC3,ESR2,FABP6,FADS1,FDPS,FIS1,GNPAT,GSTK1,HAO2,HMGCL,HRAS,HSD11B2,HSD17B11,HSD17B4,HSD3B7,IDE,IDH1,IDH2,IDI1,ISOC1,ITGB1BP1,LONP2,MLYCD,MSH2,MVP,NR1I2,NUDT19,PABPC1,PEX11A,PEX11B,PEX13,PEX14,PEX2,PEX5,PEX6,PRDX1,PRDX5,RDH11,RETSAT,RXRG,SCGB1A1,SCP2,SEMA3C,SERPINA6,SIAH1,SLC23A2,SLC25A17,SLC25A19,SLC25A4,SLC27A2,SLC35B2,SMARCC1,SOD1,SOD2,STS,SULT2B1,TOP2A,TSPO,TTR,UGT2B17,VPS4B,YWHAH |
| HALLMARK_PI3K_AKT_MTOR_SIGNALING | ACACA,ACTR2,ACTR3,ADCY2,AKT1,AKT1S1,AP2M1,ARF1,ARHGDIA,ARPC3,ATF1,CAB39,CAB39L,CALR,CAMK4,CDK1,CDK2,CDK4,CDKN1A,CDKN1B,CFL1,CLTC,CSNK2B,CXCR4,DAPP1,DDIT3,DUSP3,E2F1,ECSIT,EGFR,EIF4E,FASLG,FGF17,FGF22,FGF6,GNA14,GNGT1,GRB2,GRK2,GSK3B,HRAS,HSP90B1,IL2RG,IL4,IRAK4,ITPR2,LCK,MAP2K3,MAP2K6,MAP3K7,MAPK1,MAPK10,MAPK8,MAPK9,MAPKAP1,MKNK1,MKNK2,MYD88,NCK1,NFKBIB,NGF,NOD1,PAK4,PDK1,PFN1,PIK3R3,PIKFYVE,PIN1,PITX2,PLA2G12A,PLCB1,PLCG1,PPP1CA,PPP2R1B,PRKAA2,PRKAG1,PRKAR2A,PRKCB,PTEN,PTPN11,RAC1,RAF1,RALB,RIPK1,RIT1,RPS6KA1,RPS6KA3,RPTOR,SFN,SLA,SLC2A1,SMAD2,SQSTM1,STAT2,TBK1,THEM4,TIAM1,TNFRSF1A,TRAF2,TRIB3,TSC2,UBE2D3,UBE2N,VAV3,YWHAB |
| HALLMARK_PROTEIN_SECRETION | ABCA1,ADAM10,ANP32E,AP1G1,AP2B1,AP2M1,AP2S1,AP3B1,AP3S1,ARCN1,ARF1,ARFGAP3,ARFGEF1,ARFGEF2,ARFIP1,ATP1A1,ATP6V1B1,ATP6V1H,ATP7A,BET1,BNIP3,CAV2,CD63,CLCN3,CLN5,CLTA,CLTC,COG2,COPB1,COPB2,COPE,CTSC,DNM1L,DOP1A,DST,EGFR,ERGIC3,GALC,GBF1,GLA,GNAS,GOLGA4,GOSR2,ICA1,IGF2R,KIF1B,KRT18,LAMP2,LMAN1,M6PR,MAPK1,MON2,NAPA,NAPG,OCRL,PAM,PPT1,RAB14,RAB22A,RAB2A,RAB5A,RAB9A,RER1,RPS6KA3,SCAMP1,SCAMP3,SCRN1,SEC22B,SEC24D,SEC31A,SGMS1,SH3GL2,SNAP23,SNX2,SOD1,SSPN,STAM,STX12,STX16,STX7,TMED10,TMED2,TMX1,TOM1L1,TPD52,TSG101,TSPAN8,USO1,VAMP3,VAMP4,VAMP7,VPS45,VPS4B,YIPF6,YKT6,ZW10 |
| HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY | ABCC1,ATOX1,CAT,CDKN2D,EGLN2,ERCC2,FES,FTL,G6PD,GCLC,GCLM,GLRX,GLRX2,GPX3,GPX4,GSR,HHEX,HMOX2,IPCEF1,JUNB,LAMTOR5,LSP1,MBP,MGST1,MPO,MSRA,NDUFA6,NDUFB4,NDUFS2,NQO1,OXSR1,PDLIM1,PFKP,PRDX1,PRDX2,PRDX4,PRDX6,PRNP,PTPA,SBNO2,SCAF4,SELENOS,SOD1,SOD2,SRXN1,STK25,TXN,TXNRD1,TXNRD2 |
| HALLMARK_SPERMATOGENESIS | ACE,ACRBP,ACRV1,ACTL7B,ADAD1,ADAM2,ADCYAP1,AGFG1,AKAP4,ALOX15,ARL4A,ART3,AURKA,BRAF,BUB1,CAMK4,CCNA1,CCNB2,CCT6B,CDK1,CDKN3,CFTR,CHFR,CHRM4,CLGN,CLPB,CLVS1,CNIH2,COIL,CRISP2,CSNK2A2,CST8,DBF4,DCC,DDX25,DDX4,DMC1,DMRT1,DNAJB8,DPEP3,ELOVL3,EZH2,GAD1,GAPDHS,GFI1,GMCL1,GPR182,GRM8,GSG1,GSTM3,H1-6,HBZ,HOXB1,HSPA1L,HSPA2,HSPA4L,HTR5A,IDE,IFT88,IL12RB2,IL13RA2,IP6K1,JAM3,KIF2C,LDHC,LPIN1,MAP7,MAST2,MEP1B,MLF1,MLLT10,MTNR1A,MTOR,NAA11,NCAPH,NEFH,NEK2,NF2,NOS1,NPHP1,NPY5R,OAZ3,ODF1,PACRG,PAPOLB,PARP2,PCSK1N,PCSK4,PDHA2,PEBP1,PGK2,PGS1,PHF7,PHKG2,PIAS2,POMC,PRKAR2A,PRM2,PSMG1,RAD17,RFC4,RPL39L,SCG3,SCG5,SEPTIN4,SHE,SIRT1,SLC12A2,SLC2A5,SNAP91,SPATA6,STAM2,STRBP,SYCP1,TALDO1,TCP11,TEKT2,THEG,TKTL1,TLE4,TNNI3,TNP1,TNP2,TOPBP1,TSN,TSSK2,TTK,TUBA3C,TULP2,VDAC3,YBX2,ZC2HC1C,ZC3H14,ZNRF4,ZPBP |
| HALLMARK_TGF_BETA_SIGNALING | ACVR1,APC,ARID4B,BCAR3,BMP2,BMPR1A,BMPR2,CDH1,CDK9,CDKN1C,CTNNB1,ENG,FKBP1A,FNTA,FURIN,HDAC1,HIPK2,ID1,ID2,ID3,IFNGR2,JUNB,KLF10,LEFTY2,LTBP2,MAP3K7,NCOR2,NOG,PMEPA1,PPM1A,PPP1CA,PPP1R15A,RAB31,RHOA,SERPINE1,SKI,SKIL,SLC20A1,SMAD1,SMAD3,SMAD6,SMAD7,SMURF1,SMURF2,SPTBN1,TGFB1,TGFBR1,TGIF1,THBS1,TJP1,TRIM33,UBE2D3,WWTR1,XIAP |
| HALLMARK_TNFA_SIGNALING_VIA_NFKB | ABCA1,ACKR3,AREG,ATF3,ATP2B1,B4GALT1,B4GALT5,BCL2A1,BCL3,BCL6,BHLHE40,BIRC2,BIRC3,BMP2,BTG1,BTG2,BTG3,CCL2,CCL20,CCL4,CCL5,CCN1,CCND1,CCNL1,CCRL2,CD44,CD69,CD80,CD83,CDKN1A,CEBPB,CEBPD,CFLAR,CLCF1,CSF1,CSF2,CXCL1,CXCL10,CXCL11,CXCL2,CXCL3,CXCL6,DENND5A,DNAJB4,DRAM1,DUSP1,DUSP2,DUSP4,DUSP5,EDN1,EFNA1,EGR1,EGR2,EGR3,EHD1,EIF1,ETS2,F2RL1,F3,FJX1,FOS,FOSB,FOSL1,FOSL2,FUT4,G0S2,GADD45A,GADD45B,GCH1,GEM,GFPT2,GPR183,HBEGF,HES1,ICAM1,ICOSLG,ID2,IER2,IER3,IER5,IFIH1,IFIT2,IFNGR2,IL12B,IL15RA,IL18,IL1A,IL1B,IL23A,IL6,IL6ST,IL7R,INHBA,IRF1,IRS2,JAG1,JUN,JUNB,KDM6B,KLF10,KLF2,KLF4,KLF6,KLF9,KYNU,LAMB3,LDLR,LIF,LITAF,MAFF,MAP2K3,MAP3K8,MARCKS,MCL1,MSC,MXD1,MYC,NAMPT,NFAT5,NFE2L2,NFIL3,NFKB1,NFKB2,NFKBIA,NFKBIE,NINJ1,NR4A1,NR4A2,NR4A3,OLR1,PANX1,PDE4B,PDLIM5,PER1,PFKFB3,PHLDA1,PHLDA2,PLAU,PLAUR,PLEK,PLK2,PLPP3,PMEPA1,PNRC1,PPP1R15A,PTGER4,PTGS2,PTPRE,PTX3,RCAN1,REL,RELA,RELB,RHOB,RIGI,RIPK2,RNF19B,SAT1,SDC4,SERPINB2,SERPINB8,SERPINE1,SGK1,SIK1,SLC16A6,SLC2A3,SLC2A6,SMAD3,SNN,SOCS3,SOD2,SPHK1,SPSB1,SQSTM1,STAT5A,TANK,TAP1,TGIF1,TIPARP,TLR2,TNC,TNF,TNFAIP2,TNFAIP3,TNFAIP6,TNFAIP8,TNFRSF9,TNFSF9,TNIP1,TNIP2,TRAF1,TRIB1,TRIP10,TSC22D1,TUBB2A,VEGFA,YRDC,ZBTB10,ZC3H12A,ZFP36 |
| HALLMARK_UNFOLDED_PROTEIN_RESPONSE | ALDH18A1,ARFGAP1,ASNS,ATF3,ATF4,ATF6,ATP6V0D1,BAG3,BANF1,CALR,CCL2,CEBPB,CEBPG,CHAC1,CKS1B,CNOT2,CNOT4,CNOT6,CXXC1,DCP1A,DCP2,DCTN1,DDIT4,DDX10,DKC1,DNAJA4,DNAJB9,DNAJC3,EDC4,EDEM1,EEF2,EIF2AK3,EIF2S1,EIF4A1,EIF4A2,EIF4A3,EIF4E,EIF4EBP1,EIF4G1,ERN1,ERO1A,EXOC2,EXOSC1,EXOSC10,EXOSC2,EXOSC4,EXOSC5,EXOSC9,FKBP14,FUS,GEMIN4,GOSR2,H2AX,HERPUD1,HSP90B1,HSPA5,HSPA9,HYOU1,IARS1,IFIT1,IGFBP1,IMP3,KDELR3,KHSRP,KIF5B,LSM1,LSM4,MTHFD2,MTREX,NABP1,NFYA,NFYB,NHP2,NOLC1,NOP14,NOP56,NPM1,PAIP1,PARN,PDIA5,PDIA6,POP4,PREB,PSAT1,RPS14,RRP9,SDAD1,SEC11A,SEC31A,SERP1,SHC1,SKIC3,SLC1A4,SLC30A5,SLC7A5,SPCS1,SPCS3,SRPRA,SRPRB,SSR1,STC2,TARS1,TATDN2,TSPYL2,TUBB2A,VEGFA,WFS1,WIPI1,XBP1,XPOT,YIF1A,YWHAZ,ZBTB17 |
| HALLMARK_UV_RESPONSE_DN | ABCC1,ACVR2A,ADD3,ADGRL2,ADORA2B,AGGF1,AKT3,AMPH,ANXA2,ANXA4,APBB2,ARHGEF9,ATP2B1,ATP2B4,ATP2C1,ATRN,ATRX,ATXN1,BCKDHB,BDNF,BHLHE40,BMPR1A,CACNA1A,CAP2,CAV1,CCN1,CDC42BPA,CDK13,CDKN1B,CDON,CELF2,CITED2,COL11A1,COL1A1,COL1A2,COL3A1,COL5A2,DAB2,DBP,DDAH1,DLC1,DLG1,DMAC2L,DUSP1,DYRK1A,EFEMP1,ERBB2,F3,FBLN5,FHL2,FYN,FZD2,GCNT1,GJA1,GRK5,HAS2,ICA1,ID1,IGF1R,IGFBP5,INPP4B,INSIG1,IRS1,ITGB3,KALRN,KCNMA1,KIT,LAMC1,LDLR,LPAR1,LTBP1,MAGI2,MAP1B,MAP2K5,MAPK14,MET,MGLL,MGMT,MIOS,MMP16,MRPS31,MT1E,MTA1,MYC,NEK7,NFIB,NFKB1,NIPBL,NOTCH2,NR1D2,NR3C1,NRP1,PDGFRB,PDLIM5,PEX14,PHF3,PIAS3,PIK3CD,PIK3R3,PLCB4,PLPP3,PMP22,PPARG,PRDM2,PRKAR2B,PRKCA,PRKCE,PTEN,PTGFR,PTPN21,PTPRM,RASA2,RBPMS,RGS4,RND3,RUNX1,RXRA,SCAF8,SCHIP1,SCN8A,SDC2,SERPINE1,SFMBT1,SIPA1L1,SLC22A18,SLC7A1,SMAD3,SMAD7,SNAI2,SPOP,SRI,SYNE1,SYNJ2,TENT4A,TFPI,TGFBR2,TGFBR3,TJP1,TOGARAM1,VAV2,VLDLR,WDR37,YTHDC1,ZMIZ1 |
| HALLMARK_UV_RESPONSE_UP | ABCB1,ACAA1,AGO2,ALAS1,ALDOA,AMD1,AP2S1,APOM,AQP3,ARRB2,ASNS,ATF3,ATP6V1C1,ATP6V1F,BAK1,BCL2L11,BID,BMP2,BSG,BTG1,BTG2,BTG3,C4BPB,CA2,CASP3,CCK,CCND3,CCNE1,CDC34,CDC5L,CDK2,CDKN1C,CDKN2B,CDO1,CEBPG,CHKA,CHRNA5,CLCN2,CLTB,CNP,COL2A1,CREG1,CTSV,CXCL2,CYB5B,CYB5R1,CYP1A1,DDX21,DGAT1,DLG4,DNAJA1,DNAJB1,E2F5,EIF2S3,EIF5,ENO2,EPCAM,EPHX1,FEN1,FGF18,FKBP4,FMO1,FOS,FOSB,FURIN,GAL,GCH1,GGH,GLS,GPX3,GRINA,GRPEL1,H2AX,HLA-F,HMOX1,HNRNPU,HSPA13,HSPA2,HTR7,HYAL2,ICAM1,IGFBP2,IL6,IL6ST,IRF1,JUNB,KCNH2,KLHDC3,LHX2,LYN,MAOA,MAPK8IP2,MARK2,MGAT1,MMP14,MRPL23,MSX1,NAT1,NFKBIA,NKX2-5,NPTX2,NPTXR,NR4A1,NTRK3,NUP58,NXF1,OLFM1,ONECUT1,PARP2,PDAP1,PDLIM3,PLCL1,POLE3,POLG2,POLR2H,PPAT,PPIF,PPP1R2,PPT1,PRKACA,PRKCD,PRPF3,PSMC3,PTPRD,RAB27A,RASGRP1,RET,RFC4,RHOB,RPN1,RRAD,RXRB,SELENOW,SHOX2,SIGMAR1,SLC25A4,SLC6A12,SLC6A8,SOD2,SPR,SQSTM1,STARD3,STIP1,STK25,SULT1A1,TACR3,TAP1,TARS1,TCHH,TFRC,TGFBRAP1,TMBIM6,TST,TUBA4A,TYRO3,UROD,WIZ,YKT6 |
| HALLMARK_WNT_BETA_CATENIN_SIGNALING | ADAM17,AXIN1,AXIN2,CCND2,CSNK1E,CTNNB1,CUL1,DKK1,DKK4,DLL1,DVL2,FRAT1,FZD1,FZD8,GNAI1,HDAC11,HDAC2,HDAC5,HEY1,HEY2,JAG1,JAG2,KAT2A,LEF1,MAML1,MYC,NCOR2,NCSTN,NKD1,NOTCH1,NOTCH4,NUMB,PPARD,PSEN2,PTCH1,RBPJ,SKP2,TCF7,TP53,WNT1,WNT5B,WNT6 |
| HALLMARK_XENOBIOTIC_METABOLISM | ABCC2,ABCC3,ABCD2,ABHD6,ACO2,ACOX1,ACOX2,ACOX3,ACP1,ACP2,ACSM1,ADH1C,ADH5,ADH7,AHCY,AKR1C2,AKR1C3,ALAS1,ALDH2,ALDH3A1,ALDH9A1,ANGPTL3,AOX1,AP4B1,APOE,AQP9,ARG1,ARG2,ARPP19,ASL,ATOH8,ATP2A2,BCAR1,BCAT1,BLVRB,BPHL,CA2,CASP6,CAT,CBR1,CCL25,CD36,CDA,CDO1,CES1,CFB,CNDP2,COMT,CROT,CRP,CSAD,CYB5A,CYFIP2,CYP17A1,CYP1A1,CYP1A2,CYP26A1,CYP27A1,CYP2C18,CYP2E1,CYP2J2,CYP2S1,CYP4F2,DCXR,DDAH2,DDC,DDT,DHPS,DHRS1,DHRS7,ECH1,ELOVL5,ENPEP,ENTPD5,EPHA2,EPHX1,ESR1,ETFDH,ETS2,F10,F11,FABP1,FAH,FAS,FBLN1,FBP1,FETUB,FMO1,FMO3,G6PC1,GABARAPL1,GAD1,GART,GCH1,GCKR,GCLC,GCNT2,GNMT,GSR,GSS,GSTA3,GSTM4,GSTO1,GSTT2,HACL1,HES6,HGFAC,HMOX1,HNF4A,HPRT1,HRG,HSD11B1,HSD17B2,ID2,IDH1,IGF1,IGFBP1,IGFBP4,IL1R1,IRF8,ITIH1,ITIH4,JUP,KARS1,KYNU,LCAT,LEAP2,LONP1,LPIN2,MAN1A1,MAOA,MARCHF6,MBL2,MCCC2,MPP2,MT2A,MTHFD1,NDRG2,NFS1,NINJ1,NMT1,NPC1,NQO1,PAPSS2,PC,PDK4,PDLIM5,PEMT,PGD,PGRMC1,PINK1,PLG,PMM1,POR,PPARD,PROS1,PSMB10,PTGDS,PTGES,PTGES3,PTGR1,PTS,PYCR1,RAP1GAP,RBP4,REG1A,RETSAT,SAR1B,SERPINA6,SERPINE1,SERTAD1,SHMT2,SLC12A4,SLC1A5,SLC22A1,SLC35B1,SLC35D1,SLC46A3,SLC6A12,SLC6A6,SMOX,SPINT2,SSR3,TAT,TDO2,TGFB2,TKFC,TMBIM6,TMEM176B,TMEM97,TNFRSF1A,TPST1,TTPA,TYR,UGDH,UPB1,UPP1,VNN1,VTN,XDH |
