| Details |
| Disease Name | Alzheimer Disease |
| Nocoding RNA Name | 51A |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time quantitative RT-PCR,Immunofluorescence,Western Blot etc. |
| Target | N/A |
| Tissue | brain |
| Treatment | N/A |
| PubMed ID | 22996644 |
| Year | 2013 |
| Detail Description | a non-coding (nc) RNA (hereafter referred to as 51A) that maps in antisense configuration to intron 1 of the SORL1 gene. 51A expression drives a splicing shift of SORL1 from the synthesis of the canonical long protein variant A to an alternatively spliced protein form. This process, resulting in a decreased synthesis of SORL1 variant A, is associated with impaired processing of amyloid precursor protein (APP), leading to increased Aβ formation. Interestingly, we found that 51A is expressed in human brains, being frequently upregulated in cerebral cortices from individuals with Alzheimer’s disease. |
NSDNA: The Nervous System Disease NcRNAome Atlas
Contact wanglh211@163.com for inquiries and feedback
© All right reserved 2016