| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | ADAMTS9-AS2 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time quantitative PCR,Western Blot,siRNA etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 24833086 |
| Year | 2014 |
| Detail Description | ADAMTS9-AS2 expression was significantly downregulated in tumor tissues compared with normal tissues and reversely associated with tumor grade and prognosis. Multivariate analysis of the prognosis factors showed that low ADAMTS9-AS2 expression was a significant independent predictor of poor survival in glioma. Overexpression of ADAMTS9-AS2 resulted in significant inhibition of cell migration in glioma, whereas knockdown of ADAMTS9-AS2 showed the opposite effect. We also found that ADAMTS9-AS2 expression was negatively correlated with DNA methyltransferase-1 (DNMT1). In addition, DNMT1 knockdown led to remarkable enhancement of ADAMTS9-AS2 expression. By 5-aza-dC treatment, the ADAMTS9-AS2 expression was also reactivated. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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