| Details |
| Disease Name | Alzheimer Disease |
| Nocoding RNA Name | BACE1AS |
| Expression Pattern | up-regulated |
| Species | Mus musculus |
| Detection Methods | Northern Blot,RNAi,vitro knockdown etc. |
| Target | N/A |
| Tissue | brain |
| Treatment | N/A |
| PubMed ID | 18587408 |
| Year | 2008 |
| Detail Description | we identify a conserved noncoding antisense transcript forb-secretase-1 (BACE1), a crucial enzyme in Alzheimer’s disease pathophysiology. The BACE1-antisense transcript (BACE1-AS) regulates BACE1 mRNA and subsequently BACE1 protein expressionin vitro andin vivo. Upon exposure to various cell stressors including amyloid-b1-42(Ab1-42), expression of BACE1-AS becomes elevated, increasing BACE1 mRNA stability and generating additional Ab1-42 through a post-transcriptional feed-forward mechanism.BACE1-AS concentrations were elevated in subjects with Alzheimer’s disease and in amyloid precursor protein transgenic mice. |
NSDNA: The Nervous System Disease NcRNAome Atlas
Contact wanglh211@163.com for inquiries and feedback
© All right reserved 2016