| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | CASC2 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | quantitative RT-PCR,Cell proliferation assay,Luciferase Reporter Assay,RNA immunoprecipitation etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 25446261 |
| Year | 2015 |
| Detail Description | CASC2 was lowly expressed in glioma tissues as well as in U251 and U87 glioma cell lines. Overexpression of CASC2 inhibited the malignancy of glioma cells, including proliferation, migration, and invasion, and promoted cell apoptosis. We found that up-regulated CASC2 decreased the expression of miR-21 significantly and there is a reciprocal repression between CASC2 and miR-21 in an Argonaute2-dependent manner. Furthermore, bioinformatics, luciferase reporter assays and pull-down assay confirmed that miR-21 binds to CASC2 in a sequence-specific manner. Introduction of miR-21 largely abrogated CASC2-mediated inhibition of glioma cell proliferation, migration, and invasion, and promotion of cell apoptosis. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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