| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | CRNDE |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR,Cell proliferation assay,Luciferase Reporter Assay,Cell transfection,Western Blot etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 26231038 |
| Year | 2015 |
| Detail Description | CRNDE expression was up-regulated while miR-186 expression was down-regulated in GSCs. Overexpression of CRNDE could promote the cellular proliferation, migration, invasion and inhibit the apoptosis in GSCs. Overexpression of miR-186 exerted functions of inhibiting the proliferation, migration and invasion of GSCs and promoting apoptosis. And CRNDE decreased the expression levels of XIAP and PAK7 by binding to miR-186 and negatively regulating it. In addition, miR-186 binded to XIAP and PAK7 3'UTR region, and decrease the expression of them, thus regulating the expression levels of downstream target proteins such as caspase 3, BAD, cyclin D1 and MARK2. The in vivo effect of CRNDE and miR-186 showed that the tumor formation rate was minimum in tumor-bearing nude mice with the knockdown of CRNDE and the overexpression of miR-186. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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