NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Neuroblastoma
Nocoding RNA Name	Dali
Expression Pattern	associated
Species	Homo sapiens
Detection Methods	qRT-PCR,vitro knockdown etc.
Target	N/A
Tissue	neuroblastoma cell lines
Treatment	N/A
PubMed ID	25415054
Year	2014
Detail Description	Dali is transcribed downstream of the Pou3f3 transcription factor gene and its depletion disrupts the differentiation of neuroblastoma cells. Locally, Dali transcript regulates transcription of the Pou3f3 locus. Distally, it preferentially targets active promoters and regulates expression of neural differentiation genes, in part through physical association with the POU3F3 protein. Dali interacts with the DNMT1 DNA methyltransferase in mouse and human and regulates DNA methylation status of CpG island-associated promoters in trans.

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