| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | FOXM1-AS |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Immunofluorescence,immunohistochemistry,Luciferase Reporter Assay,qRT-PCR,microarray etc. |
| Target | ALKBH5 |
| Tissue | tumor |
| Treatment | N/A |
| PubMed ID | 28344040 |
| Year | 2017 |
| Detail Description | We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs). Silencing ALKBH5 suppresses the proliferation of patient-derived GSCs. Integrated transcriptome and m6A-seq analyses revealed altered expression of certain ALKBH5 target genes, including the transcription factor FOXM1. ALKBH5 demethylates FOXM1 nascent transcripts, leading to enhanced FOXM1 expression. Furthermore, a long non-coding RNA antisense to FOXM1 (FOXM1-AS) promotes the interaction of ALKBH5 with FOXM1 nascent transcripts.Depleting ALKBH5 and FOXM1-AS disrupted GSC tumorigenesis through the FOXM1 axis. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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