NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Glioblastoma
Nocoding RNA Name	H19
Expression Pattern	up-regulated
Species	Homo sapiens
Detection Methods	Real-time quantitative RT-PCR,Chromatin immunoprecipitation,siRNA etc.
Target	N/A
Tissue	glioblastoma cell lines
Treatment	N/A
PubMed ID	16707459
Year	2006
Detail Description	c-Myc significantly induces the expression of the H19 noncoding RNA in diverse cell types, including breast epithelial, glioblastoma, and fibroblast cells. c-Myc binds to evolutionarily conserved E-boxes near the imprinting control region to facilitate histone acetylation and transcriptional initiation of the H19 promoter. In addition, c-Myc down-regulates the expression of insulin-like growth factor 2 (IGF2), the reciprocally imprinted gene at the H19/IGF2 locus.

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