| Disease Name |
Glioblastoma |
| Nocoding RNA Name |
H19 |
| Expression Pattern |
up-regulated |
| Species |
Homo sapiens |
| Detection Methods |
Real-time quantitative RT-PCR,immunohistochemistry etc. |
| Target |
N/A |
| Tissue |
brain(brain tumor tissue) |
| Treatment |
N/A
|
| PubMed ID |
26274999 |
| Year |
2015 |
| Detail Description |
H19 is significantly overexpressed in glioblastoma tissues, and the level of expression was associated with patient survival. In the subsequent investigations, the authors found that overexpression of H19 promotes glioblastoma cell invasion and angiogenesis in vitro. Interestingly, H19 was also significantly overexpressed in CD133+ glioblastoma cells, and overexpression of H19 was associated with increased neurosphere formation of glioblastoma cells. Finally, stable overexpression of H19 was associated with increased tumor growth in the murine xenograft model. |
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