Details
Disease Name Glioblastoma
Nocoding RNA Name H19
Expression Pattern up-regulated
Species Homo sapiens
Detection Methods Real-time quantitative RT-PCR,immunohistochemistry etc.
Target N/A
Tissue brain(brain tumor tissue)
Treatment N/A
PubMed ID 26274999
Year 2015
Detail Description H19 is significantly overexpressed in glioblastoma tissues, and the level of expression was associated with patient survival. In the subsequent investigations, the authors found that overexpression of H19 promotes glioblastoma cell invasion and angiogenesis in vitro. Interestingly, H19 was also significantly overexpressed in CD133+ glioblastoma cells, and overexpression of H19 was associated with increased neurosphere formation of glioblastoma cells. Finally, stable overexpression of H19 was associated with increased tumor growth in the murine xenograft model.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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