| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | HOTAIR |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time PCR,Transfection,Cell proliferation assay,Flow Cytometry,Luciferase Reporter Assay,Western Blot etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 26183397 |
| Year | 2015 |
| Detail Description | Quantitative RT-PCR demonstrated that HOTAIR expression was up-regulated in glioma tissues and cell lines. Knockdown of HOTAIR exerted tumor-suppressive function in glioma cells. Further, HOTAIR was confirmed to be the target of miR-326 and miR-326 mediated the tumor-suppressive effects of HOTAIR knockdown on glioma cell lines. Moreover, over-expressed miR-326 reduced the FGF1 expression which played an oncogenic role in glioma by activating PI3K/AKT and MEK 1/2 pathways. |
NSDNA: The Nervous System Disease NcRNAome Atlas
Contact wanglh211@163.com for inquiries and feedback
© All right reserved 2016