| Details |
| Disease Name | Neuroblastoma |
| Nocoding RNA Name | HOXD-AS1 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Northern Blot,qRT-PCR,siRNA etc. |
| Target | N/A |
| Tissue | neuroblastoma cell line(SH-SY5Y cells) |
| Treatment | N/A |
| PubMed ID | 25522241 |
| Year | 2014 |
| Detail Description | One of these lncRNAs, termed HOXD-AS1, is encoded in HOXD cluster. HOXD-AS1 is evolutionary conserved among hominids and has all bona fide features of a gene. Studying retinoid acid (RA) response of SH-SY5Y cell line, a model of human metastatic neuroblastoma, we found that HOXD-AS1 is a subject to morphogenic regulation, is activated by PI3K/Akt pathway and itself is involved in control of RA-induced cell differentiation. Knock-down experiments revealed that HOXD-AS1 controls expression levels of clinically significant protein-coding genes involved in angiogenesis and inflammation, the hallmarks of metastatic cancer. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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