| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | MALAT1 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time quantitative PCR,ELISA,Immunohistochemistry,siRNA etc. |
| Target | N/A |
| Tissue | glioblastoma cell lines (LN-229, LN-319, LN-18 and LN-428) |
| Treatment | N/A |
| PubMed ID | 25772239 |
| Year | 2015 |
| Detail Description | Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA and key positive regulator of invasion, emerged as the top downregulated gene. Indeed, knockdown of MALAT1 reduced migration in glioblastoma cells, without effect on proliferation. Hence, loss of WIF1 enhances the migratory potential of glioblastoma through WNT5A that activates the WNT/Ca2+ pathway and MALAT1. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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