| Details |
| Disease Name | Neuroblastoma |
| Nocoding RNA Name | MALAT1 |
| Expression Pattern | differentially expressed |
| Species | Homo sapiens |
| Detection Methods | quantitative Real-time RT-PCR,siRNA transfection,immunoblot analyses,Cell invasion assays etc. |
| Target | N/A |
| Tissue | neuroblastoma cell lines(BE(2)-C and CHP134 cells) |
| Treatment | N/A |
| PubMed ID | 24742640 |
| Year | 2014 |
| Detail Description | The long noncoding RNA MALAT1 induces lung cancer cell migration and plays a pivotal role in lung cancer metastasis. Here we demonstrated that N-Myc up-regulated the expression of JMJD1A in N-Myc oncogene-amplified human neuroblastoma cells by directly binding to the JMJD1A gene promoter. Affymetrix microarray studies revealed that the gene second most significantly up-regulated by JMJD1A was MALAT1. Consistent with this finding, RT-PCR and chromatin immunoprecipitation assays showed that JMJD1A bound to the MALAT1 gene promoter and demethylated histone H3K9 at the MALAT1 gene promoter. Moreover, JMJD1A and MALAT1 induced, while the small molecule JMJD1A inhibitor DMOG suppressed, neuroblastoma cell migration and invasion. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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