Details
Disease Name Glioma
Nocoding RNA Name MEG3
Expression Pattern down-regulated
Species Homo sapiens
Detection Methods Real-time quantitative PCR,Western Blot,Methylation-specific polymerase chain reaction etc.
Target N/A
Tissue Human glioma cell lines
Treatment 5-Aza-2'-deoxycytidine
PubMed ID 26676363
Year 2015
Detail Description downregulation of MEG3 expression due to hypermethylation of MEG3 was observed in gliomas tissues. Treatment of glioma cells with the DNA methylation inhibitor 5-Aza-2'-deoxycytidine (5-AzadC) decreased aberrant hypermethylation of the MEG3 promoter and prevented the loss of MEG3 expression.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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