| Details |
| Disease Name | Epilepsy, Temporal Lobe |
| Nocoding RNA Name | NEAT1 |
| Expression Pattern | differentially expressed |
| Species | Homo sapiens |
| Detection Methods | microarray,Western Blot,immunohistochemistry,FLIPR,Next Generation sequencing,qRT-PCR etc. |
| Target | KCNIP1 |
| Tissue | neocortex |
| Treatment | N/A |
| PubMed ID | 28054653 |
| Year | 2017 |
| Detail Description | we show that while NEAT1 is acutely down-regulated in response to neuronal activity, repeated stimulation results in NEAT1 becoming chronically unresponsive in independent in vivo rat model systems relevant to temporal lobe epilepsy. We extended previous studies showing increased NEAT1 expression in resected cortical tissue from high spiking regions of patients suffering from intractable seizures. Our results indicate a role for NEAT1 in modulating human neuronal activity and suggest a novel mechanistic link between an activity-dependent long non-coding RNA and epilepsy. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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