| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | NEAT1 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target | SOX5 |
| Tissue | human brain EC line hCMEC/D3,The human glioblastoma cell line U87 MG, U251MG |
| Treatment | N/A |
| PubMed ID | 28185956 |
| Year | 2017 |
| Detail Description | NEAT1 was remarkably up-regulated in glioma endothelial cells (GECs). Knockdown of NEAT1 impaired the integrity and increased the permeability of the BTB, accompanied by downregulation of expression of the tight junction proteins ZO-1, occludin and claudin-5 in GECs.NEAT1 influenced BTB permeability by binding to miR-181d-5p. Knockdown of NEAT1 also down-regulated the expression of sex determining region Y-box protein 5 (SOX5), which was defined as a direct and functional downstream target of miR-181d-5p. SOX5 interacts with the promoter region of ZO-1, occludin and claudin-5 in GECs. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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