| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | NEAT1 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Flow Cytometry,qRT-PCR,Western Blot etc. |
| Target | CDK6 |
| Tissue | Human glioblastoma cell line U87 |
| Treatment | N/A |
| PubMed ID | 27878295 |
| Year | 2017 |
| Detail Description | We found higher NEAT1 RNA expression in CD133+ human glioma primary culture stem cells and CD133+ U87 cells via RT-PCR. NEAT1 knockdown in the CD133+ U87 cells resulted in decreased colony formation, increased G1 cell cycle arrest and apoptosis. In addition, these effects were accompanied by miR-107 activation and inactivation of CDK6 protein. These results strongly suggest that NEAT1 knockdown suppresses stem-like properties in glioma cells by modulating the miR-107CDK6 pathway. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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