| Details |
| Disease Name | Amyotrophic Lateral Sclerosis |
| Nocoding RNA Name | NEAT1_2 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Quantitative RT-PCR,EM-ISH,Immunoblotting etc. |
| Target | N/A |
| Tissue | spinal cord |
| Treatment | N/A |
| PubMed ID | 23835137 |
| Year | 2013 |
| Detail Description | TDP-43 and FUS/TLS were enriched in paraspeckles and bound to NEAT1_2 lncRNA directly. The paraspeckles were localized apart from the Cajal bodies, which were also known to be related to RNA metabolism. Analyses of 633 human spinal motor neurons in six ALS cases showed NEAT1_2 lncRNA was upregulated during the early stage of ALS pathogenesis. In addition, localization of NEAT1_2 lncRNA was identified in detail by electron microscopic analysis combined with ISH for NEAT1_2 lncRNA. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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