| Disease Name |
Glioma |
| Nocoding RNA Name |
PVT1 |
| Expression Pattern |
up-regulated |
| Species |
Homo sapiens |
| Detection Methods |
qRT-PCR,Western Blot,Luciferase Reporter Assay,immunohistochemistry etc. |
| Target |
Beclin1 |
| Tissue |
surgically resected glioma samples |
| Treatment |
N/A
|
| PubMed ID |
28351322 |
| Year |
2017 |
| Detail Description |
The long non-coding RNA PVT1 was found to be highly expressed in glioma vascular endothelial cells. PVT1 overexpression increased the expression of Atg7 and Beclin1 by targeting miR-186, which induced protective autophagy, thus promoting glioma vascular endothelial cell proliferation, migration, and angiogenesis. |
|