| Details |
| Disease Name | Neuroblastoma |
| Nocoding RNA Name | Paupar |
| Expression Pattern | associated |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR,Flow Cytometry,ChIP,vitro knockdown etc. |
| Target | N/A |
| Tissue | neuroblastoma cell lines(N2A cells) |
| Treatment | N/A |
| PubMed ID | 24488179 |
| Year | 2014 |
| Detail Description | we describe the genomically local and more distal functions of Paupar, a vertebrate-conserved and central nervous system-expressed lncRNA transcribed from a locus upstream of the gene encoding the PAX6 transcription factor. Knockdown of Paupar disrupts the normal cell cycle profile of neuroblastoma cells and induces neural differentiation. Paupar acts in a transcript-dependent manner both locally, to regulate Pax6, as well as distally by binding and regulating genes on multiple chromosomes, in part through physical association with PAX6 protein. Paupar binding sites are enriched near promoters and can function as transcriptional regulatory elements whose activity is modulated by Paupar transcript levels. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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