| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | TP73-AS1 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target | HMGB1 |
| Tissue | human brain glioma cells, U118, U251, SNB119, LN229 and SHG-44 |
| Treatment | N/A |
| PubMed ID | 28379612 |
| Year | 2017 |
| Detail Description | TP73-AS1 was specifically upregulated in brain glioma tissues and cell lines and was associated with poorer prognosis in patients with glioma. TP73-AS1 knocking down suppressed human brain glioma cell proliferation and invasion in vitro, as well as HMGB1 protein.TP73-AS1 and miR-142 could negatively regulate each other. TP73-AS1 might compete with HMGB1 for miR-142 binding. HMGB1/RAGE was involved in TP73-AS1/miR-142 regulation of glioma cell proliferation and invasion. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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