| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | TUG1 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | microarray,qRT-PCR,immunohistochemistry,Flow Cytometry,Western Blot etc. |
| Target | Notch1 |
| Tissue | surgically resected glioma samples |
| Treatment | N/A |
| PubMed ID | 27922002 |
| Year | 2016 |
| Detail Description | Notch1 activation in GSCs specifically induces expressionof the lncRNA, TUG1. TUG1 coordinately promotes self-renewal by sponging miR-145 in the cytoplasm and recruiting polycomb to repress differentiation genes by locus-specific methylation of histone H3K27 via YY1-binding activity in the nucleus. Furthermore, intravenous treatment with antisense oligonucleotides targeting TUG1 coupled with a drug delivery system induces GSC differentiation and efficiently represses GSC growth in vivo. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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