| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | XIST |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR,Western Blot,Immunofluorescence,Luciferase Reporter Assay etc. |
| Target | FOXC1 |
| Tissue | human brain EC line hCMEC/D3,Human glioma cell lines U87MG, U118MG |
| Treatment | N/A |
| PubMed ID | 28287613 |
| Year | 2017 |
| Detail Description | XIST was upregulated in endothelial cells that were obtained in a BTB model in vitro. XIST knockdown increased BTB permeability and inhibited glioma angiogenesis. The reduction of XIST inhibited the expression of the transcription factor forkhead box C1 (FOXC1) and zonula occludens 2 (ZO-2) by upregulating miR-137. FOXC1 decreased BTB permeability by increasing the promoter activity and expression of ZO-1 and occludin, and promoted glioma angiogenesis by increasing the promoter activity and expression of chemokine (C–X–C motif) receptor 7b (CXCR7). |
NSDNA: The Nervous System Disease NcRNAome Atlas
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