Details
Disease Name Alzheimer Disease
Nocoding RNA Name cel-let-7
Expression Pattern up-regulated
Species Caenorhabditis elegans
Detection Methods RT-PCR,X-gal staining etc.
Target apl-1
Tissue Caenorhabditis elegans
Treatment N/A
PubMed ID 18262516
Year 2008
Detail Description C.elegans apl-1 shows significant genetic interactions with let-7 family microRNAs and let-7-targeted heterochronic genes,hbl-1,lin-41 and lin-42.apl-1 expression is upregulated during the last larval stage in hypodermal seam cells which is transcriptionally regulated by hbl-1,lin-41 and lin-42.Moreover,the levels of the apl-1 transcription are modulated by the activity of let-7 family microRNAs.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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