NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Lafora Disease
Nocoding RNA Name	hsa-let-7
Expression Pattern	associated
Species	Homo sapiens
Detection Methods	Immunoblotting,Immunoprecipitation etc.
Target	N/A
Tissue	HeLa cell lines
Treatment	N/A
PubMed ID	23131811
Year	2012
Detail Description	Defects in malin are associated with Lafora disease (LD)—a neurodegenerative disorder characterized by myoclonus seizures. We show here that malin is recruited to the processing bodies and that malin regulates the recruitment of mRNA decapping enzyme Dcp1a by promoting its degradation via the ubiquitin proteasome system. Depletion of malin results in elevated levels of Dcp1a and an altered microRNA-mediated gene silencing activity.

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