| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-let-7b |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | microarray,Real-time PCR etc. |
| Target | cyclin D1 |
| Tissue | glioblastoma cell lines |
| Treatment | cisplatin |
| PubMed ID | 23806108 |
| Year | 2013 |
| Detail Description | microRNA microarray containing 3100 probes to analyze differential miRNA expression profiles in U251 and U251R cell lines.23 miRNAs are up-regulated and 16 miRNAs are down-regulated in U251R cells.The microarray results were then validated by real time PCR. Consistent with microarray data, miR-182 and miR-224 were up-regulated in U251R cells; Let-7b,miR-125b, miR-107 and miR-203 were significantly suppressed in U251R cells.Overexpression of Let-7b mimics suppressed cyclin D1 protein expression and inhibited cyclin D1-3’-UTR luciferase activity. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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