| Details |
| Disease Name | Alzheimer Disease |
| Nocoding RNA Name | hsa-miR-103 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Luciferase Reporter Assay etc. |
| Target | ADAM10 |
| Tissue | SH-SY5Y cells |
| Treatment | N/A |
| PubMed ID | 22594617 |
| Year | 2012 |
| Detail Description | Eleven miRNAs were selected, which have evolutionary conserved binding sites. Three of them (miR-103,miR-107, miR-1306) were further analysed as they are linked to AD and most strictly conserved between different species. Predicted target genes of miR-103 (p-value = 0.0065) and miR-107 (p-value = 0.0009) showed significant overlap with the AlzGene database except for miR-1306. Interactions between miR-103 and miR-107 to genes were revealed playing a role in processes leading to AD. ADAM10 expression in the reporter assay was reduced by miR-1306 (28%), miR-103 (45%) and miR-107 (52%). |
NSDNA: The Nervous System Disease NcRNAome Atlas
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