| Disease Name |
Glioblastoma |
| Nocoding RNA Name |
hsa-miR-10b |
| Expression Pattern |
up-regulated |
| Species |
Homo sapiens |
| Detection Methods |
Taqman miRNA reverse transcription,Invasion assay etc. |
| Target |
FOXO3 |
| Tissue |
glioblastoma cell lines |
| Treatment |
N/A
|
| PubMed ID |
23034333 |
| Year |
2012 |
| Detail Description |
Expression of miR-10b is elevated in invasive mesenchymal subtype-like U87-2M1 glioma cells, silencing of miRNA-10b by baculoviral decoy vectors in a glioma cell line resembling the mesenchymal subtype of GBM reduces its growth, invasion and angiogenesis while promoting apoptosis in vitro. Identification of TP53, FOXO3, CYLD, NOTCH1, PTCH1 and PAX6 as targets of miR-10b. |
|