| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-10b |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR etc. |
| Target | E2F1 |
| Tissue | glioblastoma cell lines |
| Treatment | N/A |
| PubMed ID | 25738367 |
| Year | 2015 |
| Detail Description | MicroRNA-10b (miR-10b) is commonly elevated in glioblastoma (GBM), while not expressed in normal brain tissues.inhibition of miR-10b has distinct effects on specific glioma cell lines. In cells expressing high levels of tumor suppressor p21WAF1/Cip1, it represses E2F1-mediated transcription, leading to down-regulation of multiple E2F1 target genes encoding for S-phase specific proteins, epigenetic modulators, and miRNAs (e.g. miR-15/16), and thereby stalling progression through the S-phase of cell cycle. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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