| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-124a |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | qPCR,transfection,Methylation Specific PCR etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | 5-aza-2'-deoxycytidine |
| PubMed ID | 24068568 |
| Year | 2014 |
| Detail Description | Loss of miR-124a has been attributed to hypermethylation while other studies have shown miR-124a to be regulated by the repressor-element-1-silencing transcription factor (REST,also known as neuron-restrictive silencing factor).Hypermethylation of miR-124a was observed in 82% of GBM patient specimens (n=56). In vitro miR-124a expression levels also increased after treatment of several patientderived cell lines with 5-aza-2′-deoxycytidine. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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